NOEC and LOEC (no and lowest observed effect concentrations, respectively) are toxicological concepts derived from analysis of variance (ANOVA), a not very sensitive method that produces ambiguous results and does not provide confidence intervals (CI) of its estimates. For a long time, despite the abundant criticism that such concepts have raised, the field of the ecotoxicology is reticent to a...

Biotechnology is evolving at a tremendous rate. Although drug discovery is now heavily focused on high throughput and miniaturized screening, the application of these advances to the toxicological assessment of chemicals and chemical products has been slow. Nevertheless, the impending surge in demands for the regulatory toxicity testing of chemicals provides the impetus for the incorporation of...

Ginkgo biloba extract (GBE; CASRN 90045-36-6) is a commonly used herbal supplement. A comprehensive toxicological assessment by the NTP identified GBE as hepatotoxic. The constituents of GBE can vary across lots, hence the question arises as to how representative the lot tested by NTP is of other lots of GBE and by extension to what degree the results of the NTP hazard characterization are more...

Purpose. To determine the optimal combination and consumption of coagulants flocculants in treatment drilling wastewater, followed by determination acute lethal toxicity obtained illuminated liquid phase. Methods. Primary clarification phase waste was carried out method chemical coagulation using organic "Magnafloc" "ECOFLOC" as a coagulant. In case insufficient degree purification wastewater m...

Green petroleum coke is primarily inorganic carbon with some entrained volatile hydrocarbon material. As part of the petroleum industry response to the high production volume challenge program, the potential for reproductive effects was assessed in a subchronic toxicity/reproductive toxicity screening test in rats (OECD 421). The repeated-dose portion of the study provided evidence for dust acc...

The SGVs and the additional advice found here should be used only in conjunction with the introductory guide to the series entitled Using Soil Guideline Values (Environment Agency, 2009a), the framework documents Updated technical background to the CLEA model (Environment Agency, 2009b) and Human health toxicological assessment of contaminants in soil (Environment Agency, 2009c), and Contaminan...