Sialic acid-poor low density lipoprotein (LDL) is suggested to be atherogenic because it causes in vitro accumulation of cholesterol into epithelial cells and macrophages. We studied whether the whole-body catabolism of LDL varies according to its sialic acid content by analyzing the sialic acids in total (d 1.019-1.063 g/ml), light (d 1.019-1.036 g/ml), dense (d 1.037-1.055 g/ml), and very den...

Some investigators have reported recently that platelet surface sialic acid is decreased during ADP-induced aggregation, whereas others have reported an increase. Since removal of sialic acid from the platelet surface shortens platelet survival, we have determined the survival of platelets that have been aggregatad by ADP. We have also measured the amount of sialic acid in the suspending fluid ...

total cholesterol and significantly lower in a group with high concentrations of HDL cholesterol. Serum triglyceride showed a positive significant correlation with serum sialic acid and HDL cholesterol showed a negative significant correlation. These findings suggest that the serum concentration of sialic acid is affected by serum lipids. Increases in serum sialic acid concentration in patients...

A comparative study of the sialic acid content of semen, serum and spermatozoa from several mammalian species was made. The sialic acid content of semen showed a very wide range of concentration in the four species examined, while the sialic acid concentrations in serum were much more uniform. The semen from man and bull contained higher concentrations of sialic acid than the serum of these res...

Previous studies have shown that epididymal epithelium and its secretions are critical for sperm maturation. These secretions contain many glycoconjugates with sialic acid terminal sugar. This terminal sugar by interveining in cellular interactions and masking surface receptors, has an important role in sperm maturation and protection. Moreover lectins have been employed as useful probes to det...

BACKGROUND Detection of cancer at an early stage is of utmost importance to decrease the morbidity and mortality of the disease. Apart from the conventional biopsy, non-invasive methods like analysis of serum and saliva may provide cost-effective approach for screening a large population. Tumor markers are a major part of secondary prevention and thus, the detection of malignancies. The aim of ...

BACKGROUND Smokeless tobacco chewing is one of the known risk factors for oral cancer. It is consumed widely by residents of southeastern Iran. OBJECTIVES In this study, salivary free and total sialic acid, and total protein were compared in paan consumers and non-consumers. PATIENTS AND METHODS In this cross-sectional study, unstimulated saliva of 94 subjects (44 paan consumers and 50 non-...

Sialic acids are substituted neuraminic acid derivatives which are typically found at the outermost end of glycan chains on the membrane in all cell types. The role of erythrocyte membrane sialic acids during aging has been established however the relationship between sialic acid and oxidative stress is not fully understood. The present work was undertaken to analyze the relationship between er...