We investigated the impact of three marriageable actions: normal-to-carrier, carrier-to-normal, and carrier-to-carrier marriages on thalassemia carrier populations. The well-known strategy is limiting marriage to reduce population. Thus, other two actions were often ignored. Other than a simple explanation their genetic consequences, important aspect in inheritance mechanism has never been stud...

Alpha Thalassemia is one of the most prevalent disorders worldwide with a [T1] high carrier rate in Mazandaran province (north of Iran). Carriers of --MED double gene deletion are at risk of having a child with hemoglobin  haemoglobin[T2]  H (HbH) disease, if they marry a silent carrier. Co-inheritance of αααAnti3.7 triplication that cannot be detected using hem...

objective(s): iran is considered as one of the high-prevalence areas for β-thalassemia with a rate of about 10% carrier frequency. molecular diagnosis of the disease is performed both by direct sequencing and indirectly by the use of polymorphic markers present in the beta globin gene cluster. however, to date there is no reliable information on the application of the markers in the iranian pop...

objective: this study was designed to investigate rbc indices and hba2 levels in parents of major beta-thalassemia patients to detect possible silent beta- thalassemia carriers and examine its potential impact on the premarital genetic counseling. materials and methods: this cross sectional study was performed at children medical center from 2004 to 2006. after genetic counseling and getting in...

Homozygous thalassemia is due to inherited unbalanced synthesis of the alpha- or beta-chains of hemoglobin. Clinical severity may be in part related to the extent of alpha:beta imbalance. Two families are presented that illustrate this concept. Thalassemia in these individuals was evaluated by clinical and genetic criteria. The relative rates of alpha- and beta-chain synthesis in their reticulo...

We report a retrospective analysis carried out on 23,485 subjects submitted to a screening program from 2000 to 2006. Of these subjects, 3,934 had borderline HbA(2) values from 3.1 to 3.9%; 410 samples, analyzed previously using PCR methods and sequencing because all of these were partners of a carrier of classical beta-thalassemia, were selected for statistical analysis. Of 410 subjects, 94 (2...

It has recently been estimated that each year, more than seven million babies worldwide are born with either a congenital abnormality or a genetic disease.1 Hemoglobinopathies are the commonest autosomal hereditary disorders and present a major public health problem in India. The overall prevalence of the -thalassemia trait is 2.78% but this varies from 1.48 to 3.64% in different states of Indi...

Corresponding Author: Mohammad Reza Mahdavi Fajr Medical Laboratory, Keshavarz Blvd. Sari, Iran. Phone: +98-1133292929 E-mail: [email protected] Abstract Background: Alpha Thalassemia is one of the most prevalent disorders worldwide with a high carrier rate in Mazandaran province (north of Iran). Carriers of --MED double gene deletion are at risk of having a child with haemoglobin H (HbH)...

Sickle cell-thalassemia associated with glucose- 6-phosphate dehydrogenese deficiency is re­ported in an Iranian family. The father had sickle trait and G.6.P.D. deficiency, the mother minor thalassemia, one of the sons siclc:le ceH-thailasemiia., the oth-er sickle cell trait; the daughter had sickle cell-thalassemia and was carrier of G.6.P.D. deficiellcy.