the effect of a new anthelmintic compound, leavo-tetramisole, in the mass-treatment of several intestinal helminthes has been evaluated during a study undertaken among the population of the village of zavieh hajian, located about 10 km northwest of dezful, khuzestan.in the autumn of 1972, a total of 83 inhabitants, 65 of whom were simultaneously infected with ascaris, hookworm (ancylostoma) and...

A sufficient differentiation of lymphatic capillaries from blood capillaries in conventional light microscopy still eludes researches. The endothelium and media of lymphatic capillaries are characterized by a strong 5'-nucleotidase activity, whereas blood capillaries reveal no or significantly lower activity. Alkaline phosphatase activity, on the other hand, missing in the lymphatic capillaries...

Levamisole, the levo-isomer of tetramisole, is readily soluble in water and is rapidly absorbed from the gastro intestinal tract; peak blood levels are achieved after 1.5–4 h. Its plasma half-life is 16 h and it is metabolized mainly in the liver.[1,3] Usually, it is administered at a dose of 150 mg/day for 2–4 days each week but for the management of malignancies or immunodeficiencies a higher...

A stereodivergent asymmetric Lewis base catalyzed Michael addition/lactonization of enone acids into substituted dihydrobenzofuran and tetrahydrofuran derivatives is reported. Commercially available (S)-(-)-tetramisole hydrochloride gives products with high syn diastereoselectivity in excellent enantioselectivity (up to 99:1 d.r.syn/anti , 99 % eesyn ), whereas using a cinchona alkaloid derived...

The effect of combining chemotherapy and immunostimulation, induced by a chemical, against a murine lymphoid leukemia was investigated. When tetramisole or levamisole were used following one administration of 1,3-bis(2-chloroethyl)-l-nitrosourea, a significantly higher percentage of long-term surviviors occurred in contrast to the groups of animals treated with drug or immunostimulant alone. Th...