Marijuana is the most commonly abused illicit drug by pregnant women in the world. Its psychoactive cannabinoid, 9 -tetrahydrocannabinol, crosses the placenta and accumulates in the fetus, potentially harming its development. In humans, marijuana use in early pregnancy is associated with an increased risk for miscarriage, anencephaly, as well as subtle neurodevelopmental defects in the offsprin...

Delta(9)-tetrahydrocannabinol binds cannabinoid (CB(1) and CB(2)) receptors, which are activated by endogenous compounds (endocannabinoids) and are involved in a wide range of physiopathological processes (e.g. modulation of neurotransmitter release, regulation of pain perception, and of cardiovascular, gastrointestinal and liver functions). The well-known psychotropic effects of Delta(9)-tetra...

A liquid chromatography-tandem mass spectrometry single-laboratory validation was performed for the detection and quantification of the 10 major cannabinoids of cannabis, namely, (-)-trans-Δ9-tetrahydrocannabinol, cannabidiol, cannabigerol, cannabichromene, tetrahydrocannabivarian, cannabinol, (-)-trans-Δ8-tetrahydrocannabinol, cannabidiolic acid, cannabigerolic acid, and Δ9-tetrahydrocannabino...

(-)-∆9-Tetrahydrocannabinol is the principal psychoactive component of the cannabis plant and also the active ingredient in some prescribed drugs. To detect and control misuse and monitor administration in clinical settings, reference samples of the native drugs and their metabolites are needed. The accuracy of liquid chromatography/mass spectrometric quantification of drugs in biological sampl...

A simple and reliable gas chromatography-mass spectrometry method for identifying and quantifying psychoactive drugs in oral fluid is described. Substances under investigation were: psychostimulant drugs (amphetamine, methamphetamine, 3,4-methylenedioxymethamphetamine, 3,4-methylenedioxiamphetamine, 3,4-methylenedioxy-N-ethylamphetamine, phentermine), cocaine and metabolites (benzoylecgonine, c...

The stability of Δ9‒tetrahydrocannabinol acetate (Δ9‒THC‒OAc) and Δ8‒tetrahydrocannabinol (Δ8‒THC‒OAc) in e-liquid during storage was investigated. Δ9‒THC‒OAc liquids cartridges were stored at 80℃ or 30℃ for 28 days. relative concentrations cannabinoids the measured by gas chromatography with flame ionization detection. decreased either temperature. Δ9‒THC, a minor impurity, also decreased. Δ8‒...

In the life sciences, automation solutions are primarily established in field of drug discovery. However, there is also an increasing need for automated medical diagnostics, e.g., determination vitamins, medication or abuse. While actual metrological highly today, necessary sample preparation processes still mainly carried out manually. laboratory, flexible required that can be used to determin...