poultry spermatogonial stem cells (sscs) have the potential to serve as a model for studying the basic biology of ssc and they can also be used for biotechnological purposes. however, the small number of sscs and the presence of the testicular somatic cells with sscs have limited their applications. therefore, this study was undertaken for the first time to investigate the effect of a serum-fre...

background:gossypol is a yellow toxic pigment from the cottonseed that can cause acute or chronic toxicity in humans and animals by affecting the testicular tissues. nowadays cottonseed is used as food supplement for ruminants specially the sheep. in this study, two different stem cell lines of testicular tissue including gc1-spg (mouse testis) and sftf-pi43 (sheep testis) cells were used to ev...

Background: Formaldehyde is a chemical that used in fixed tissues and bodies. Formaldehyde during dissection of cadaver, evaporate and be released. Studies have shown that the gas increase endogenous opioids, nitric oxide and cytokines in plasma. These impacts can affect on gonadotropin hormones. The aim of this study was to investigate possible changes in gonadotropin and epithelial cells of t...

Background: Hyperprolactinemia is a particular concern in the treatment of schizophrenic patients. The side effects associated with high prolactin levels can have a negative impact on GnRH pulsatile secretion and, consequently LH, FSH and testosterone pulsatility and follows by, on special testicular cells that have these hormon’s receptors such as sertoli and leydig cells. Quantification the d...

background: testicular torsion is a medical emergency that requires surgical intervention to reperfuse the affected testis. ischemia reperfusion injury is usually associated with proinflammatory cytokine generation and apoptosis of germ cells in the testes.objective: in this study we investigate the effect of ghrelin on the proinflammatory cytokines levels and germ cell apoptosis in testicular ...

background: in cancer patients, chemo and radiotherapy can cause infertility by damaging spermatogenesis process. this process is based on self-renewal and differentiation of a rare population of the testicular cells called spermatogonial stem cells (sscs). scientists have tried to isolate, enrich and culture human spermatogonial stem cells, hoping to resolve infertility problems in cancer reco...

Background: Ceftriaxone is an antibiotic used for treating respiratory,skin,bone and kidney infections. Our purpose was investigating effect of ceftriaxone on testicular tissue. Materials and Methods: 40 mice with 6 weeks old were used in this study. The mice randomly were divided into 2 groups, control- sham and test groups. The test group was subdivided to IP1 and IP2 which received Ceftriaxo...

Abstract Diabetes mellitus (DM) is one of the greatest public health threats in modern societies. Although during a few years it was suggested that DM had no significant effect in male reproductive function, this view has been challenged in recent years. From a clinical perspective, the evaluation of semen parameters, as well as spermatozoa deoxyribonucleic acid (DNA) integrity, are often st...