Abstract The genus Taxus (yew) is a source of number high-value medicinal substances, particularly, paclitaxel (taxol)—a complex diterpenoid compound with powerful antitumor action (trade name Taxol®). Paclitaxel one the most efficient drugs in chemotherapy owing to its specific ability suppress proliferation tumor cells via stabilization their microtubules. world-wide demand for taxol 800–1000...

Seasonal variations of the phytochemicals contents in needles of T. wallichiana var. mairei due to the effects of growth meteorological parameters were investigated in this study. The needles of T. wallichiana var. mairei were collected from different months and the contents of taxoids (paclitaxel, 10-deacetylbaccatin III (10-DAB), baccatin III, cephalomannine, 10-deacetyltaxol (10-DAT)), flavo...

Four sets of experimental data were investigated in terms of normal distribution and presence of outliers. The following sets of compound were investigated: blood-brain barrier partitioning (n=105), inhibitory activity of para-substituted aromatic sulfonamides (n=47), inhibition activity of taxoids (n=63), and estrogen receptor binding affinity of triphenilacrylonitriles (n=25). The normality o...

BACKGROUND Multidrug resistance has been associated with expression of the multidrug resistance protein (MRP). Recently, MRP-expression has been detected in human tumor samples of patients with breast cancer and non-small-cell lung cancer. Since taxoids are the most active drugs in the treatment of both tumor entities, the antitumor efficacies of paclitaxel and docetaxel were compared in nude m...

The synchrotron x-ray solution scattering profiles of microtubules assembled from purified GDP- or GTP-tubulin with the antitumor drug docetaxel (Taxotere) are consistent with identical non-globular alpha and beta-tubulin monomers ordered within the known surface lattice of microtubules, with a center to center lateral spacing of 5.7 +/- 0.1 nm. The higher angle part of the scattering profile, ...