Taste is the most crucial organoleptic parameter affecting patient compliance in case of drugs with poor palatability. masking a major challenge for development orally ingested active pharmaceutical constituents industry. Numerous conventional taste-masking techniques have been extensively studied. In parallel, drug solubility or release concern techniques. Recently, many nanocarrier systems in...

The purpose of this research was to develop and evaluate pediatric formulation by masking the bitter taste of Isoniazid.Non-compliance of therapy of tuberculosis which is mostly associated with bitter taste can lead to worsening of diseased condition in children. Cationic resin utilized to mask the bitter taste of Isoniazidby preparing resinate complex. Syrup preparation evaluated for drug cont...

The masking of bitterness is considered important because many pharmaceutical compounds have a bitter taste. The bitterness-masking effect of powdered roasted soybeans (PRS) was investigated using a bitter taste sensor. PRS was revealed to significantly suppress the bitterness of quinine hydrochloride and denatonium benzoate. Furthermore, the bitterness-masking mechanism of PRS extracts was eva...

BACKGROUND Currently, acute upper respiratory tract infections (AURTIs) are increasingly becoming a significant health burden. Gankeshuangqing dispersible tablets (GKSQDT) which have a good effect on treating AURTIs. GKSQDT is composed of baicalin and andrographolide. However, its severe bitterness limits application of patients. Due to the addition of plentiful accessories, common masking meth...

Detection thresholds for sodium chloride were compared in aqueous solution, in mixture with a sucrose masker, in mixture with a citric acid masker, and in mixture with both of these maskers together. Separately the two maskers raised the threshold of sodium chloride by three to four times, and together by over nine times, a result consistent with independence (additivity) of the two masking eff...

Taste has an important role in the development of oral pharmaceutical formulation. With respect to patient acceptability and compliance, taste is one of the prime factors determining the market penetration and commercial success of oral formulations, especially in pediatric medicine. Taste assessment is one important quality-control tool for evaluating taste-masked formulations. Hence, pharmace...

Orally Disintegrating Tablets (ODT) have the advantages of both solid dosage form specially the stability and ease of handling and liquid dosage forms including ease of swallowing and pre-gastric absorption. We focused on taste masking and formulation of ranitidine ODT which disintegrates rapidly in the mouth within 60 sec using super-disintegrants, special polymers, water soluble and even inso...

The demand for mouth dissolving tablets has been growing, during the last decade especially for geriatric and pediatric patients because of swallowing difficulties. The purpose of this research was to mask the intensely bitter taste of Ondansetron HCl and to formulate a orodispersible of the taste-masked drug. Taste masking was done by complexing Ondansetron HCl with Kyron T-134 in different ra...