the effect of tamoxifen citrate on bone mass in immobilization osteoporosis was studied in 10 dogs.osteoporosis was induced by fiberglass cast immobilization of the right hind-limb for 28 days, while the lefthind-limb served as a non-immobilized control. five dogs received tamoxifen citrate (1.5 mg/kg per os) once daily for 28 days; five dogs received no treatment. all dogs were euthanized on d...

abstract background: tamoxifen, a synthetic anti-estrogen agent, is administered as an adjuvant treatment in breast cancer. since various studies have indicated that tamoxifen can change some hormones and bound globolines, controversial results have been achieved using this medicine on thyroid functional tests (tft). the present study was conducted to investigate the effects of tamoxifen on tft...

apoptosis could be a major mechanism of antitumor effect of tamoxifen. therefore this study is designed to characterize the kinetic behavior of tamoxifen-induced apoptosis in the estrogen receptor positive (er+) and negative (er-) cell lines, mcf-7 and mda-mb-468. frequency of cell death was examined by trypan blue and acridine orange staining. annexin v-fluorescein/pi was used in flow cytometr...

Apoptosis could be a major mechanism of antitumor effect of tamoxifen. Therefore this study is designed to characterize the kinetic behavior of tamoxifen-induced apoptosis in the estrogen receptor positive (ER+) and negative (ER-) cell lines, MCF-7 and MDA-MB-468. Frequency of cell death was examined by trypan blue and acridine orange staining. Annexin V-Fluorescein/PI was used in flow cytometr...

background: tamoxifen treatment induced cell death in the hippocampus formation of the prenatal and postnatal rat. the present study delineates the effect of tamoxifen on developing hippocampus in prenatal, postnatal and full term neonate rats received certain doses of the partial antagonist tamoxifen. methods: after perfusion and fixation, the brains were removed and processed for light and el...

It has been reported that CXCL12 binding to CXCR4 induces several intracellular signaling pathways, and enhances survival, proliferation, and migration of malignant cells. Herein we examined the effects of anti-estrogen tamoxifen and anti-allergic tranilast drugs as a single or in combination on invasion by two in vitro invasion assays, wound-healing and matrigel invasion on MCF-7 and MDA-MB-23...

it has been reported that cxcl12 binding to cxcr4 induces several intracellular signaling pathways, and enhances survival, proliferation, and migration of malignant cells. herein we examined the effects of anti-estrogen tamoxifen and anti-allergic tranilast drugs as a single or in combination on invasion by two in vitro invasion assays, wound-healing and matrigel invasion on mcf-7 and mda-mb-23...

The effect of tamoxifen citrate on bone mass in immobilization osteoporosis was studied in 10 dogs.Osteoporosis was induced by fiberglass cast immobilization of the right hind-limb for 28 days, while the lefthind-limb served as a non-immobilized control. Five dogs received tamoxifen citrate (1.5 mg/kg per os) once daily for 28 days; five dogs received no treatment. All dogs were euthanized on d...