The metabolism of benzo(a)pyrene in cultured human colon has been investigated. Nontumorous colonie tissue was collected at the time of either surgery or "immediate autopsy" from patients with or without colonie cancer. After 24 hr in culture the expiants were exposed to [3H]benzo(a)pyrene for another 24 hr and the binding to cellular DMA and protein was measured. Two adducts, formed between be...

The metabolism,by short-termorgancufturesof rat and hamstertrachea, of benzo(a)pyreneand its primaryme tabolites, 4,5-dihydro-4,5-dihydroxybenzo(a)pyrene (4,5dihydrodiol), 7,8-dihydro-7,8-dihydroxybenzo(a)pyrene (7,8dihydrodiol), 9,1O-dihydro-9,1O-dihydroxybenzo(a)pyrene (9,1 0-dihydrodiol), and 3-hydroxybenzo(a)pyrene, to their majorethylacetate-solubleandwater-solublemetabolites has been stud...

Enterocytes protect themselves from the detergent actions of intracellular bile acids by expressing the ileal bile acid binding protein (encoded by the IBABP gene), which facilitates the movement of the detergents across the cell and their secretion into the portal circulation. Over the last three decades, much progress has been When they reach the liver, the bile acids are taken up made in und...

constant and variable sequences which may occur either at the level of DNA or RNA. It is now generally accepted, that both B and T lymphocytes directly participate in antigen recognition, but the existence and nature of T cell receptors is still debated. Some could not find them; others could, but found them passively absorbed. When they were detected, they looked IgM-like (IgT) or like IgA wit...

The metabolism of benzo(a)pyrene in cultured human colon has been investigated. Nontumorous colonie tissue was collected at the time of either surgery or "immediate autopsy" from patients with or without colonie cancer. After 24 hr in culture the expiants were exposed to [3H]benzo(a)pyrene for another 24 hr and the binding to cellular DMA and protein was measured. Two adducts, formed between be...

hydrochloride (10 mg three times a day for as long as 20 days) did not affect values for 17-hydroxycorticosteroids. In vitro data do show that there is a small increase in the apparent value for urinary 17-hydroxycorticosteroids when chlordiazepoxide or its lactam or N-despiethyl metabolite is added to urine. However, this increase does not appear to be large enough to be of significance. The f...

The arachidonic acid cascade generates a family of bioactive lipids that modulate diverse physiological and pathophysiological responses. Although there has been a great deal of interest in the involvement of arachidonic acid metabolites in cancer, there is uncertainty about which metabolites are the most im portant and how they contribute to specific steps in cell trans formation, tumor growth...

Traumatic brain injury (TBI) is a complex disorder with variable eti-ology and severity that nowadays stands as a major cause of death and disability worldwide, principally among children and young people. Despite the implementation of intensive care strategies at early stages following the injury, long-term morbidity of severe TBI still remains high, and many patients may show significant neur...

461 base used for the original analysis is predominantly that seen in normal patients, while the critical interpretation is the sick patient. This reviewer, for example, recently saw a liver with extensive metastases proven to be over 4700 g at necropsy (3 times normal weight) measured as normal approximately 2 weeks before death by the author's techniques in the author's nuclear facility. It w...

The effects of chromium methionine supplementation on performance and serummetaboliteswere evaluated in broiler chickens.Two experiments were conducted at22 oC, thermoneutral, (TN) and33±2 oC, heat stressed (HS) conditions. Two hundred and eighty eight male broiler chicks (Ross 308) were allocated to four treatments in a completely randomized design. Treatments with 0 (control), 200, 400 or 800...