نتایج جستجو برای: t2dm
تعداد نتایج: 7233 فیلتر نتایج به سال:
Introduction: Type 2 diabetes mellitus (T2DM) is an inflammatory disease with alterations in immune system. Remarkably, cytokine imbalance plays an important role in pathogenesis of T2DM. The purpose of this study was to determine the serum levels of TNF-α, IL-1β and IL-10 and the effects of sitagliptin on the level of these cytokines in patients with T2DM. Materials and Methods: Blood samples ...
Diabetic dyslipidemia is one of the leading causes of coronary artery disease (CAD) death. Genetic and environmental factors play an important role in the development of type 2 diabetes mellitus (T2DM) and dyslipidemia. The present study was aimed to investigate the association of ACE (rs4646994), FABP2 (rs1799883), MTHFR (rs1801133) and FTO (rs9939609) genetic polymorphism in T2DM with dyslipi...
Background: The aim of this study was to identify major dietary patterns in Iranian adults and their associations with the risk of type 2 diabetes (T2DM). Methods: This nested case-control study was conducted among 698 women and men with a mean age of 43.6 ± 12.0 years in the Tehran Lipid and Glucose Study (TLGS). Among participants who were free of T2DM at baseline and developed T2...
the aim was to compare the predictive power for type 2 diabetes mellitus (t2dm) using dynamic change (difference) of metabolic syndrome (ms), difference of fasting plasma glucose (fpg), baseline ms and fpg in cohort study.overall, 3461 subjects were recruited from prevention of multiple metabolic disorders and ms in jiangsu of china study with 3.8 years follow-up. cox proportional-hazards regre...
Type 2 Diabetes Mellitus (T2DM) is a metabolic disorder influenced by interactions between genetic and environmental factors. Epigenetics conveys specific environmental influences into phenotypic traits through a variety of mechanisms that are often installed in early life, then persist in differentiated tissues with the power to modulate the expression of many genes, although undergoing time-d...
Abstract The prevalence of type 2 diabetes (T2DM) is higher in peripheral artery disease (PAD) than coronary (CAD) patients, and PAD overall confers cardiovascular risk CAD. purpose this study was to investigate how the incidence major events compares between CAD patients when analyses are stratified by presence (T2DM). We prospectively recorded death over 10.0±4.7 years 923 with stable CAD, wh...
Objective: Apolipoprotein B (APOB) plays an important role in the metabolism of cholesterol and impairment in its function can lead to cholesterol accumulation in the pancreatic islets. It can then reduce insulin secretion and lead to Type 2 diabetes (T2DM). The purpose of this study was to investigate the association of 3chr('39')APOB-VNTR polymorphism with plasma lipid profiles in T2DM indivi...
Objective(s): Epidemiological and biochemical studies conducted over the past two decades have established a strong link between type 2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD). However, the exact mechanisms through which aberrations in insulin signaling associated with T2DM contribute to cognitive decline are not yet known. Materials and Methods: In an effort to explore possible m...
Background and purpose: Type 2 diabetes mellitus (T2DM) as a progressive metabolic disorder is rising very fast around the world. Diagnosis of T2DM at early stages (prediabetic) is important in reducing the mortality associated with this disease. Several studies have shown that micro-RNAs play a major role in the pathogenesis of the T2DM. Because of the high stability of these regulatory RNA i...
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