The current study examined the relationship between renal cell carcinoma-related risk and gene polymorphisms in interleukin-10, vitamin D receptor cytochrome P450 1A1 genes. Using preferred reporting items for systematic reviews meta-analyses criteria, link carcinoma was studied by utilizing Web of Science, Embase, PubMed Wanfang databases. CC TT genotypes along with interleukin-10-819C/T C-all...

Mutations affect the genes that encode certain cytochromes P450 (CYP450) isoenzymes are responsible for metabolism of drugs. The aim this study was to determine frequency CYP2B6 (516G>T) SNP in Burkinabè population. Genomic DNA extraction from blood performed by GenJET® according manufacturer’s instructions. Genotyping cytochrome variant alleles using predesigned primers. amplification carri...

Abstract Background Matrix metalloproteinase 9 (MMP-9) is an important inflammatory marker in diabetic nephropathy. Many studies assessed the association between MMP-9 gene polymorphism and different microvascular complications of type 2 diabetes mellitus, though results were inconclusive need further exploration. Our study aimed to assess -1562C/T nephropathy patients with mellitus. Results Ta...

We investigated the association between CASP-9 polymorphisms and susceptibility to neoplasm. Fourteen studies with a total of 2733 neoplasm cases and 3352 healthy controls were included. Meta-analysis showed that the rs4645981 T allele and the rs4645981 T allele carrier were positively associated with neoplasm susceptibility [odds ratio (OR) = 1.43, 95% confidence interval (95%CI) = 1.12-1.81, ...

Urokinase might play a role in the formation of kidney stones. This study was done to determine the association between +4065 T/C polymorphism at the 3′-untranslated region of urokinase gene and calcium kidney stones. This Case-Control study was carried out on 70 cases with a history of calcium kidney stones and 70 controls from the Baqiyatallah hospital of Tehran in 2013. The study of polymorp...

Abstract Purpose To study the features of course uncontrolled arterial hypertension (AH) in Aral Sea region with identification prevalence various genotypes angiotensinogen (AGT) gene patients uncomplicated hypertensive crisis. Methods The genetic part included 94 crisis, an average age 55.3±8.6 years, 54 (58.3%)women and 40 men (41.7%). control group consisted 50 healthy women men, 52.7±6.4 ye...