The aim of present study is to exist a novel super disintegrants in fast dissolving tablet. Guar gum is a natural substance and used in many pharmaceutical product and it can also used as a super disintegrating agent in fast dissolving tablet. The result is that it released the 99.21% drug in 15min as compared to Sodium Starch Glycolate (SSG), where only 97.51% drug was released. The onset of t...

The object of the study was to formulate and evaluate Aceclofenac orodispersible tablets (ODT) by wet granulation method using different super disintegrants in different concentrations. Orodispersible tablets produce rapid dissolution of drug and absorption thereby producing rapid onset of action. Five batches (AFD1, AFD2, AFD3, AFD4, AFD5) of Aceclofenac orodispersible tablets were prepared an...

Efavirenz (EFV) tablets of different doses were prepared by a wet granulation process using different superdisintegrants such as crosscarmellose sodium (CCS), sodium starch glycollate (SSG) and crosspovidone (CP) to evaluate the role of different disintegrants on the in vitro release of EFV. Further, the mode of addition of disintegrants on EFV dissolution from tablets containing 600 mg of the ...

This study evaluates the disintegrant properties--tablet disintegration time (DT) and crushing strength--friability/disintegration time (CSFR/DT) ratio of a paracetamol tablet formulation prepared with sorghum and plantain starches in comparison with corn starch BP. The effects of disintegrant concentration, relative density of tablets and the mode of disintegrants addition were studied. The st...

With the aim of directly predicting the functionality and mechanism of disintegrants during the disintegration and dissolution of tablets, we investigated an analysis method based on available surface area, which is the surface area of a drug in a formulation in direct contact with the external solvent during dissolution. We evaluated the following disintegrants in this study: sodium starch gly...

Tizanidine HCl is a centrally acting α-2 adrenergic agonist muscle relaxant. It is slightly bitter in taste. In the present study an attempt has been made to prepare bitterless fast dissolving tablet of Tizanidine Hydrochloride using Eudragit E 100 as a taste masking agent. Mass extrusion was the technique used for preparing taste masked granules. The tablet was prepared with three super disint...

This study was performed to design bilayer floating tablets of simvastatin and lovastatin to give sustained release of simvastatin and immediate release of lovastatin. Bilayer floating tablets comprised of two layers i.e, immediate and sustained release layers. Bilayer floating tablets of simvastatin and lovastatin was formulated by using HPMCK 100M and super disintegrants like sodium alginate,...

Bilayer tablets of Metformin hydrochloride and Glipizide were formulated. Glipizide is a poor water soluble (BCS class 2) antidiabetic drug. The present study aims to increase the solubility of Glipizide by solid dispersion technique using sodium starch glycolate and crospovidone as super disintegrants. Metformin hydrochloride was formulated by using Hydroxy Propyl Methyl Cellulose as the matri...

The study evaluated two novel coprocessed excipients (with two methods) as disintegrants in an orally disintegrating paracetamol tablet formulation. The tablets produced were assessed for mechanical properties with the use of friability and tensile strength while the release properties were assessed with wetting time, water absorption ratio, disintegration time and dissolution profile. The resu...