نتایج جستجو برای: subcutaneous human adipocyte

تعداد نتایج: 1676266  

2018
Amanda Giesler Manali Mukherjee Katherine Radford Luke Janssen Parameswaran Nair

BACKGROUND Asthma and obesity, two growing epidemics worldwide, may share an underlying causal relationship. Airway hyperresponsiveness (AHR), a defining component of asthma, has been documented in both 'obese' animal models and non-asthmatic obese individuals. However, there is a paucity of evidence that obesity-derived factors directly affect human airway smooth muscles (ASM). METHODS Exper...

2012
Mi-Jeong Lee Yuanyuan Wu Susan K. Fried

Adipose stromal cells proliferate and differentiate into adipocytes, providing a valuable model system for studies of adipocyte biology. We compared differentiation protocols for human preadipocytes and report on their metabolic phenotypes. By simply prolonging the adipogenic induction period from the first 3 to 7 days, the proportion of cells acquiring adipocyte morphology increased from 30-70...

2015
Tenagne D. Challa Leon G. Straub Miroslav Balaz Elke Kiehlmann Olivier Donze Gottfried Rudofsky Jozef Ukropec Barbara Ukropcova Christian Wolfrum

There are many known adipokines differentially secreted from the different adipose depots, however, their paracrine and autocrine effects on de novo adipocyte formation are not fully understood. By developing a co-culture method of pre-adipocytes with primary subcutaneous and visceral adipocytes or tissue explants, we could show that the total secretome inhibited preadipocyte differentiation. U...

Journal: :Cells 2023

Molecular subtype (MS) is one of the most used classifications breast cancer (BC). Four MSs are widely accepted according to receptor expression estrogen, progesterone, and HER2. The impact adipose tissue on BC MS metabolic impairment still unclear. present work aims elucidate alterations in cell lines representing different subjected adipocyte associated factors. Preadipocytes isolated from hu...

2015
Joan Sanchez-Gurmaches Wen-Yu Hsiao David A. Guertin

The origins of individual fat depots are not well understood, and thus, the availability of tools useful for studying depot-specific adipose tissue development and function is limited. Cre drivers that selectively target only brown adipocyte, subcutaneous white adipocyte, or visceral white adipocyte precursors would have significant value because they could be used to selectively study individu...

Journal: :Diabetes 2015
Tenagne D Challa Leon G Straub Miroslav Balaz Elke Kiehlmann Olivier Donze Gottfried Rudofsky Jozef Ukropec Barbara Ukropcova Christian Wolfrum

There are many known adipokines differentially secreted from the different adipose depots; however, their paracrine and autocrine effects on de novo adipocyte formation are not fully understood. By developing a coculture method of preadipocytes with primary subcutaneous and visceral adipocytes or tissue explants, we could show that the total secretome inhibited preadipocyte differentiation. Usi...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2009
Carine Duffaut Alexia Zakaroff-Girard Virginie Bourlier Pauline Decaunes Marie Maumus Patrick Chiotasso Coralie Sengenès Max Lafontan Jean Galitzky Anne Bouloumié

OBJECTIVE Adipose tissue (AT) plays a major role in the low-grade inflammatory state associated with obesity. The aim of the present study was to characterize the human AT lymphocytes (ATLs) and to analyze their interactions with adipocytes. METHODS AND RESULTS Human ATL subsets were characterized by flow cytometry in subcutaneous ATs from 92 individuals with body mass index (BMI) ranging fro...

2014
Julie Lessard Sofia Laforest Mélissa Pelletier Mathieu Leboeuf Line Blackburn André Tchernof

Subcutaneous adipose tissue expansion through adipogenesis is increasingly recognized as a major determinant of body fat distribution and obesity-related cardiometabolic alterations. Our objective was to assess whether adipogenic rates of cultured human primary preadipocytes from the visceral and subcutaneous compartments relate to visceral obesity and cardiometabolic alterations. We recruited ...

Journal: :The American journal of clinical nutrition 2008
Yourka D Tchoukalova Christina Koutsari Maksym V Karpyak Susanne B Votruba Eliana Wendland Michael D Jensen

BACKGROUND Both body fat distribution and adipocyte size are associated with metabolic abnormalities. OBJECTIVE We defined the extent to which subcutaneous adipocyte size is related to regional fat mass and to the sizes of adipocytes in other subcutaneous depots independent of adiposity, age, and sex. DESIGN Data collected from 188 women and 133 men who were 18-50 y old and who had a body m...

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