نتایج جستجو برای: splenic dendritic cells
تعداد نتایج: 1411082 فیلتر نتایج به سال:
dendritic cells (dcs) are a heterogeneous family of professional apcs involved in priming adaptive immune responses. donor dcs (direct pathway of allorecognition) and recipient dcs presenting processed donor major histocompatibility complex (mhc) as peptides (indirect pathway of allorecognition) participate actively in graft rejection by stimulating recipient t cell responses following organ tr...
Dendritic cells, particularly those residing in the spleen, are thought to orchestrate acquired immunity to malaria, but it is not known how the splenic dendritic cell population responds to malaria infection and how this response compares with the responses of other antigen-presenting cells. We investigated this question for Plasmodium chabaudi AS infection in C57BL/6 mice. We found that dendr...
Background and purpose: As professional antigen- presenting cells, dendritic cells are a bridge between innate and adaptive immunity by stimulating T lymphocytes. Recent research has demonstrated the extra ability of the myeloid cells plasticity into different cells in response to environmental stimuli. In the present study, the effect of using combination maturation factors (MCM, TNF-α, poly (...
Several properties of lymphoid dendritic cells in situ have been determined, and contrasted to information previously established for lymphocytes and mononuclear phagocytes. Dendritic cells are not found in newborn mice, and their concentration in both spleen and mesenteric lymph node does not reach adult levels until 3-4 wk of age. Dendritic cells largely disappear from adherent populations fo...
RATIONALE The role of mononuclear phagocytes in chronic heart failure (HF) is unknown. OBJECTIVE Our aim was to delineate monocyte, macrophage, and dendritic cell trafficking in HF and define the contribution of the spleen to cardiac remodeling. METHODS AND RESULTS We evaluated C57Bl/6 mice with chronic HF 8 weeks after coronary ligation. As compared with sham-operated controls, HF mice exh...
BACKGROUND Blood and spleen expansion of immature myeloid cells (IMCs) might compromise the immune response to cancer. We studied in vivo circulating and splenic T lymphocyte and IMC subsets in patients with benign and malignant pancreatic diseases. We ascertained in vitro whether pancreatic adenocarcinoma (PDAC)-associated IMC subsets are induced by tumor-derived soluble factors and whether th...
Sarcoid reactions are relatively rare manifestations of epithelioid cell granulomas associated with malignancy; they are especially found in the lymph nodes draining malignant tumors, but rarely found in other organs. We present a case of a 60-year-old female with sarcoid reactions in the spleen identified during the consecutive diagnosis and management of ovarian, breast, and thyroid carcinoma...
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