Spinal tuberculosis is the commonest form of skeletal tuberculosis accounting for about 50% of osteo articular tuberculosis [1]. Spinal tuberculosis is a common infectious disease found in developing countries like India. Often patients present with Pott’s disease related paraplegia attended by "destruction of vertebral body, lamina, pedicle and spinous process with perivertebral abscess" Intra...

BACKGROUND Spinal tuberculosis is the most common form of skeletal tuberculosis. However, there were limited data to evaluate the trend of spinal tuberculosis research. This study aims to investigate the trend of spinal tuberculosis research and compare the contribution of research from different countries and authors. METHODS Spinal tuberculosis-related publications from 1994 to 2015 were re...

A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) can effectively degrade articular cartilage matrix proteoglycan and damage the intervertebral disc of spinal tuberculosis patients, resulting in deterioration of the physical properties of articular cartilage. Transforming growth factor β activated kinase 1 (TAK1) is similar to vascular cell adhesion molecule 1 (VCAM-1)...

Background: Tuberculosis is the second most common fatal infectious disease after Acquired Immunodeficiency Syndrome (AIDS) in the world. The spine is involved in 50% of osteoarticular tuberculosis cases. Tuberculous Spondylitis (TS) is the most dangerous form of osteoarticular tuberculosis, because of its ability to destroy the vertebral body with subsequent permanent kyphosis and neurological...

Tubercular spondylitis is a common extrapulmonary manifestation of tuberculosis. It accounts for 50% skeletal tuberculosis.[1] In most cases, associated symptoms are not so unique as to immediately indicate the proper diagnosis. Differentiating spinal tuberculosis from pyogenic osteomyelitis often very difficult, and metastatic lesion systemic malignancy other major entity which must be differe...

Spinal tuberculosis, also named as Pott’s disease, was first described by Percival Pott in 1779. Early diagnosis and anti-tuberculosis treatment is important for spinal tuberculosis but it is really not easy to make a diagnosis of spinal tuberculosis in some atypical patients. A 14-year-old male patient presented to our hospital in July 2013 and was diagnosed as spinal tuberculosis. He received...

Infection of the lumbosacral junction by tuberculosis is quite rare and occurs in only 1 to 2% of all cases of spinal tuberculosis; moreover, isolated sacrococcygeal or coccygeal tuberculosis is much rarer. Failure to identify and treat these areas of involvement at an early stage may lead to serious complications such as vertebral collapse, spinal compression, and spinal deformity. In the pres...

Spinal tuberculosis accounts for nearly half of all cases of musculoskeletal tuberculosis. It is primarily a medical disease and treatment consists of a multidrug regimen for 9-12 months. Surgery is reserved for select cases of progressive deformity or where neurological deficit is not improved by anti-tubercular treatment. Technology refinements and improved surgical expertise have improved th...

Considering that currently Romania has the highest tuberculosis incidence in Europe, the recognition of the infection is an acknowledged health issue. Central nervous system tuberculosis accounts for approximately 1% of all cases of tuberculosis. Longitudinally extensive transverse myelitis is a contiguous infl ammatory lesion of the spinal cord which involves three or more spinal segments. In ...