Potassium channels allow the selective flux of K⁺ excluding the smaller, and more abundant in the extracellular solution, Na⁺ ions. Here we show that Shab is a typical K⁺ channel that excludes Na⁺ under bi-ionic, Na(o)/K(i) or Na(o)/Rb(i), conditions. However, when internal K⁺ is replaced by Cs⁺ (Na(o)/Cs(i)), stable inward Na⁺ and outward Cs⁺ currents are observed. These currents show that Sha...

The activity of neurons is critically dependent upon the suite of voltage-dependent ion channels expressed in their membranes. In particular, voltage-gated K+ channels are extremely diverse in their function, contributing to the regulation of distinct aspects of neuronal activity by shaping the voltage responses. In this study the role of K+ channels in neural coding is investigated in Drosophi...

The Drosophila phototransduction cascade transforms light into depolarizations that are further shaped by activation of voltage-dependent K+ (Kv) channels. In whole-cell recordings of isolated photoreceptors, we show that light selectively modulated the delayed rectifier (Shab) current. Shab currents were increased by light with similar kinetics to the light-induced current itself (latency appr...

both nimā and al–bayāti are one of the vanguard poets in contemporary literature of iran and iraq. although it is not connection between them, but the synchronic conditions and living in analogous politic and social conditions, and inferior absolutism and stifling atmosphere, having social commitment with mulish and protester soul against society and taking up a fortified state against that, an...

The molecular structure of oxygen-sensitive delayed-rectifier K+ channels which are involved in hypoxic pulmonary artery (PA) vasoconstriction has yet to be elucidated. To address this problem, we identified the Shab K+ channel Kv2.1 and a novel Shab-like subunit Kv9.3, in rat PA myocytes. Kv9.3 encodes an electrically silent subunit which associates with Kv2.1 and modulates its biophysical pro...

The archaeological and archaeobotanical research conducted in southern part the Western Desert Egypt included efforts at identifying plant material preserved daub. samples selected for this type of analysis were taken from site E-05-1 Bargat El-Shab. This occupied seasonally by nomadic people beginning Holocene. study provide very little data on remains daub confirms application grass, as a tem...

Structural models of voltage-gated channels suggest that flexibility of the S3-S4 linker region may be important in allowing the S4 region to undergo large conformational changes in its putative voltage-sensing function. We report here the initial characterization of 18 mutations in the S3-S4 linker of the Shaker channel, including deletions, insertions, charge change, substitution of prolines,...