BACKGROUND Myostatin negatively regulates muscle growth, and its inhibition by suitable proteins can increase muscle bulk and exercise performance. However, the reference values of serum myostatin in athletes performing strength training are still lacking. METHODS A cross-sectional study recruiting28 male collegiate athletes performing strength training and 29 age-matched normal controls was ...

Myostatin, a member of the TGF−β superfamily, is a potent and specific negative regulator of skeletal muscle mass. In serum, myostatin circulates as part of a latent complex containing myostatin propeptide and/or follistatin-related gene (FLRG). Here, we report the identification of an additional protein associated with endogenous myostatin in normal mouse and human serum, discovered by affinit...

Myostatin, a member of the TGFbeta superfamily, is a potent and specific negative regulator of skeletal muscle mass. In serum, myostatin circulates as part of a latent complex containing myostatin propeptide and/or follistatin-related gene (FLRG). Here, we report the identification of an additional protein associated with endogenous myostatin in normal mouse and human serum, discovered by affin...

Sarcopenia or loss of skeletal muscle mass is a major complication of cirrhosis and liver disease. A large body of literature exists to support the prognostic significance of sarcopenia in cirrhosis. Independent clinical consequences of sarcopenia in cirrhosis include lower survival and quality of life, increases risk of complications including infections and encephalopathy, and lower post live...

OBJECTIVE Myostatin and insulin-like growth factor 1 (IGF-1) are serum markers for muscle growth and regeneration. However, their value in the clinical monitoring of Pompe disease - a muscle glycogen storage disease - is not known. In order to evaluate their possible utility for disease monitoring, we assessed the levels of these serum markers in Pompe disease patients receiving enzyme replacem...

Muscle wasting is common in advanced heart failure. Myostatin is an important modulator of muscle catabolism. We measured serum levels of myostatin and its propeptide in patients with chronic heart failure and analyzed their relationships with clinical parameters and prognosis. The study included 70 patients: 30 in New York Heart Association (NYHA) functional class I-II and 40 in class III-IV. ...

the aim of this study was to determine the effect of two kinds of resistance training and one period of detraining on serum levels of myostatin, cortisol, testosterone and muscle strength of non-athlete men. for this purpose, 34 non-athlete men (age 33.35+2.8 yr) were divided into three groups: experimental a (4 sessions of training per week), experimental b (3 sessions of training per week) an...

Myosatellite cells play an important role in mammalian muscle regeneration as they differentiate and fuse with mature fibers. In fish, they also contribute to postnatal growth and the formation of new fibers. The relative conservation of fish systems, however, is not well known nor are the underlying mechanisms that control myosatellite cell differentiation. We therefore characterized this proc...