Hesperidin nanocrystals was generated by high pressure homogenization. The physicochemical properties of a spray dried hesperidin nanocrystals were investigated including to re-dispersion, crystalline state, kinetic solubility, dissolution velocity. Hesperidin nanosuspension with concentration of 10% (w/v) was dried by a Mini Spray-dryer B-190. Photon correlation spectroscopy (PCS) and laser di...

Novel lipid nanoparticulates (NCs) were developed by a combined approach of precipitation and complexation with an aim to improve the solubility, stability and targeting efficiency of glimepiride (GLP). GLP NCs were prepared by precipitation process using PEG 20000 and further complexed with phospholipon90G (P90G). The NCs were evaluated for physicochemical characterization, such as drug lo...

The main objective of this study was to develop an effective potentiometric saturation titration protocol for determining the aqueous intrinsic solubility and the solubility-pH profile of ionizable molecules, with the specific aim of overcoming incomplete dissolution conditions, while attempting to shorten the data collection time. A modern theory of dissolution kinetics (an extension of the No...

Serum is generally considered to contain at least two proteins, albumin and globulin, differing both in their isoelectric points, (literature summarized by Freundlich) and molecular weights (Svedberg and Sj6gren), and readily separable by half-saturation with ammonium sulfate, which precipitates the globulin. There has been considerable investigation tending to show that the globulin fraction i...

The low aqueous solubility of celecoxib (CB) and thus its low bioavailability is a problem. Thus, it is suggested to improve the solubility using cosolvency and solid dispersions techniques. Pure CB has solubility of 6.26±0.23μg/ml in water but increased solubility of CB was observed with increasing concentration of cosolvents like PEG 400, ethanol and propylene glycol. Highest solubility (791....

It is important to monitor the moisture content of transformer oil in a transformer. One parameter of particular interest is the moisture solubility of transformer oil. It has been reported that transformer oils under different conditions have different solubility. Measurements of solubility for four different types of conditioned oil are presented in this paper: fresh Shell Diala AX oil, lab-a...

The aim of this study was to develop optimized sucrose ester (SE) stabilized oleanolic acid (OA) nanosuspensions (NS) for enhanced delivery via wet ball milling by design of experiments (DOE). In this study, SEOA NS batches were prepared by wet ball milling method. Mean particle sizes and polydispersity indices were determined using a nanosizer. The percent encapsulation efficiency, saturation ...

Experiments were conducted to determine CO2 solubilities in alkali basalts from Vesuvius, Etna and Stromboli. The basaltic melts were equilibrated with nearly pure CO2 at 1200°C under oxidizing conditions, and at pressures ranging from 269 to 2060 bars. CO2 solubility was determined by FTIR measurements. The results show that alkalis have a strong effect on the CO2 solubility and confirm and re...

A novel approach using a semipermeable Teflon AF-2400 tube-in-tube membrane contactor was developed for the measurement of gas solubility in organic solvents. This membrane ensures gas saturation of liquids in continuous flow at a specific pressure and temperature. After liquid decompression, the amount of gas outgassed was measured with a bubble meter and used for solubility calculation. The p...

The Viewpoint by Ran Arieli published below addresses the topic of the physiology of “mixed-gas diving.” You are invited to submit a brief commentary on this Viewpoint, which will be reviewed by Journal editors for possible publication in the Journal of Applied Physiology. Please limit your comment to 250 words and 5 peer-reviewed published references. NON-AIR OR MIXED-GAS DIVING was developed ...