the effects of some histaminergic agents were evaluated on stress- induced immunosuppression in immunized nale rats. in rat immunized with sheep red blood cells ( srbcs). restraint stress (rs) prevented the booster-induced rise in anti-srbc antibody titre and cell immunity response. intracerebroventicular (i.c>v) injection of histamine (150 µg/rat) induced a similar effect with rs. pretreatment...

OBJECTIVE This study was designed to characterize the restraint use of children in fatal crashes and to determine factors that were related to child restraint use. METHODS Crashes in which a vehicle occupant died were selected from the 1994 Fatal Analysis Reporting System data. Restraint use of children (0-9 years) in these crashes was characterized and examined in relation to vehicle and dri...

This study investigated whether application of acute restraint stress or dexamethasone, as a glucocorticoid receptor agonist, impaired retrieval of long-term memory and if pretreatment with opiate antagonist naloxone blocked their effects on memory retrieval. Young adult male rats were trained in one trial inhibitory avoidance task (1 mA, 1.5 s foot shock). On retention test given 48 hr after t...

This study investigated whether application of acute restraint stress or dexamethasone, as a glucocorticoid receptor agonist, impaired retrieval of long-term memory and if pretreatment with opiate antagonist naloxone blocked their effects on memory retrieval. Young adult male rats were trained in one trial inhibitory avoidance task (1 mA, 1.5 s foot shock). On retention test given 48 hr after t...

OBJECTIVE To investigate the association between restraint use and death in rear-seated child passengers and to examine whether the estimated association varies by restraint type and age. DESIGN Matched cohort study. SETTING All reported crashed passenger vehicles with at least 2 rear-seated child passengers of whom at least 1 died from the US Fatality Analysis Reporting System for 1998 to ...

The objective of this study was to evaluate the performance of various configurations of a driver restraint system by using a combined injury criteria index and making the restraint system adaptive to different frontal crash coinditions, such as severity of the crash, belt use, sitting position, pre-impact braking and size of the driver. For this purpose, a mathematical model of a driver restra...

Stress induced analgesia (SIA) is well known, but the reverse phenomenon, hyperalgesia is poorly documented. This study investigated the role of the histaminergic system in restraint stress hyperalgesia in rats, using thermal stimulation method (hot plate and tail flick tests). Paw licking and tail withdrawal latencies were taken before and after restraint for about one hour. Significant decrea...

OBJECTIVE Current guidelines for optimal restraint of children in motor vehicles recommend the center rear seating location for installing a child-restraint system. However, recent research on child occupants in child-restraint system has brought this into question. The objective of this study was to describe seating position patterns among appropriately restrained child occupants aged 0 to 3 y...