objective: several studies have shown the improving effect of heparin on the outcomes of art. moreover, it has been reported that adding heparin in non-thrombophilia patients with rif is useful.the aim of this study was to evaluate the beneficial effects of heparin on art outcomes in women with history of recurrent implantation failure (rif) and without history of congenital or acquired thrombo...

The success rate of reproductive treatment methods depends on many different factors. The most important and discussed ones in the literature are maternal age, the causes of infertility, the ovarian response to stimulation, the influence of the male factor and sperm quality, embryo quality and the various uterine pathologies. Some couples fail repeatedly after transferring good quality embryos ...

background: repeated implantation failure (rif) is defined as pregnancy failure after two to six times with at least ten high grade embryo transfer to uterus. a variety of causes have been anticipated for rif, including anatomical, autoimmune, genetics, endocrine and thrombotic anomalies. factors responsible for rif have important implication regarding treatment however in many couples a perfec...

BACKGROUND Implantation failure of blastocyst is one of the main reasons of failure to become pregnancy following use of Assisted Reproductive Techniques. HLA-G, one of the non-classic HLA subtypes, seems to have a vital role in neutralizing of mother immune system. According to importance of ins/del polymorphism of HLA-G in regulation of HLA-G expression, it seems that this polymorphism has an...

Background: Repeated implantation failure (RIF) is the main problem after using assisted reproductive techniques (ART). The main causes of RIF as a multifactorial problem including decrease in endometrial receptivity, defects of embryo or combinational. Successful embryo implantation depends on trophoblast proliferation, migration and invasion to the endometrium, all of which are associated wit...

Introduction Many patients who undergo assisted reproductive technology (ART) suffer from recurrent implantation failure (RIF). The addition of hyaluronic acid (HA) to the transfer medium is one several methods improve pregnancy outcomes. We investigated whether HA could live birth and clinical rates RIF patients. Methods This study included 248 patients, were divided into two groups: control (...

Recurrent implantation failure (RIF) is recognized when transferred embryos fail to implant following repeated in vitro fertilization (IVF) cycles [1]. RIF is commonly defined as the failure of implantation after three or more consecutive IVF attempts, with which 1-2 high-grade embryos were transferred in each cycle [2]. Cytotrophoblast invasion to the proper depth of the uterus secures proper ...

Recurrent implantation failure (RIF) is recognized when transferred embryos fail to implant following repeated in vitro fertilization (IVF) cycles [1]. RIF is commonly defined as the failure of implantation after three or more consecutive IVF attempts, with which 1-2 high-grade embryos were transferred in each cycle [2]. Cytotrophoblast invasion to the proper depth of the uterus secures proper ...

BACKGROUND Reproductive failure, determined as recurrent spontaneous abortions (RSA) or recurrent implantation failure (RIF) in women is not well understood. Several factors, including embryo quality, and cellular and molecular changes in endometrium may contribute to the insufficient feto-maternal interaction resulting in reproductive failure. Prior clinical studies suggest an inadequate endom...