نتایج جستجو برای: randomized clinical trials
تعداد نتایج: 1402305 فیلتر نتایج به سال:
BACKGROUND AND AIM: Randomized controlled trials (RCTs) are the gold standard for providing evidence in clinical research. The present study was performed with the objective to assess the quality of reports of RCTs in orthodontics in PubMed-indexed journals published by Iranian authors from 2007 to 2017.METHODS: All the articles on orthodontics published from 2007 to 2017 and indexed in PubMed ...
This critical review examines efficacy of CILT in comparison to traditional treatment methods for adults with aphasia as well as the efficacy of modified versions of the original CILT protocol. Study designs include: individual series pre-post treatment (3), mixed randomized clinical trial (RCT) (2), mixed non-randomized clinical trial (NRCT) (2), mixed randomized block (1) designs. Overall, re...
Several studies reported that moxibustion was effective in treating constipation. This systematic review assesses the clinical evidence for or against moxibustion for treating constipation. Twelve databases were searched from their inception to March 2010. Only randomized clinical trials (RCTs) were included if they compared moxibustion with placebo, sham treatment, drug therapy or no treatment...
Due to the scarcity of randomized clinical trials (RCTs) in nephrology [1], particularly in dialysis, there has been uncertainty about optimal practices. Using standardized data collection, the Dialysis Outcomes and Practice Patterns Study (DOPPS) has shown very large betweenand within-country differences in hemodialysis (HD) practices and patient outcomes. These observational data are especial...
The reporting of adverse events (AEs) in randomized clinical trials (RCTs) is often lacking in the publication of trials. Part of the problem is the way safety data are reported in RCTs. Reporting of "time to event," use of standardized incidence ratios for comparison to normal population or disease controls, use of "patient years" when reporting AE, and adequate sample size and power calculati...
To appraise the current reporting methodological quality of randomized clinical trials (RCTs) in 3 leading diabetes journals.We systematically searched the literature for RCTs in Diabetes Care, Diabetes and Diabetologia from 2011 to 2013.Characteristics were extracted based on Consolidated Standards of Reporting Trials (CONSORT) statement. Generation of allocation, concealment of allocation, in...
whAt Is the PRoBleM? Different from trials for regulatory approvals of new interventions aimed to test the efficacy, comparative effectiveness research (CER) is the direct comparison of existing health‐care interventions (compared with active controls) to examine which treatment works best, for whom, and under what settings.[1] Therefore, CER is indispensable to assist consumers, clinicians, pu...
IMPORTANCE The discontinuation of randomized clinical trials (RCTs) raises ethical concerns and often wastes scarce research resources. The epidemiology of discontinued RCTs, however, remains unclear. OBJECTIVES To determine the prevalence, characteristics, and publication history of discontinued RCTs and to investigate factors associated with RCT discontinuation due to poor recruitment and w...
We apply Bayesian decision analysis (BDA) to incorporate patient preferences in the regulatory approval process for new therapies. By assigning weights to type I and type II errors based on patient preferences, the significance level (α) and power (1-β) of a randomized clinical trial (RCT) for a new therapy can be optimized to maximize the value to current and future patients and, consequently,...
The randomized clinical trial (RCT) is generally accepted as the best method of comparing effects of therapies. Most often the aim of an RCT is to show that a new therapy is superior to an established therapy or placebo, i.e. they are planned and performed as superiority trials. Sometimes the aim of an RCT is just to show that a new therapy is not superior but equivalent to or not inferior to a...
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