At present, meprobamate is not a drug with a broad commercial spectrum. In order to get an optimal pharmaceutical formulation for this kind of drug or others more competitive, experimental design methodology is a statistical tool very useful for reach them. The principal aim of this work was to apply D-Optimal mixture design for optimization of meprobamate (400 mg) fast released tablets manufac...

We report on archival data from the Chandra X-ray Observatory for the radio jet of 3C120. We consider the emission process responsible for the X-rays from 4 knots using spectra constructed from radio, optical, and X-ray intensities. While a simple synchrotron model is adequate for three of the knots, the fourth (’k25’), which was previously detected by ROSAT and is now well resolved with Chandr...

PURPOSE To investigate the interpolymer complexation between Carbopol 934P (CP) and various grades of polyvinylpyrrolidone (PVP) (K90, K32, C15, and VA/S-630). METHODS Amount of fresh and dried CP-PVP complexes, water retaining capacity, apparent density, pH, conductivity, FTIR, swelling and adhesion strength were studied. RESULTS Interpolymer complexation occurred between CP and all the PV...

It is recognized that chlorin e6-polyvinylpyrrolidone (Ce6-PVP) formulations are characterized by a high efficacy in photodynamic therapy of malignant tumors. Currently, a commercially available formulation of this type is Photolon (Fotolon) with Ce6:PVP=1:1 (w/w) and the weight-average molecular weight of PVP is 1.2x10(4). To gain a better understanding of the role played by PVP in Ce6-PVP for...

The irreversible adsorption of polyvinylpyrrolidone (PVP) on a series of well-defined platinum single crystal electrode surfaces has been investigated using voltammetry, ex situ XPS and DFT calculations. It is found that the adsorption of PVP is highly structure sensitive with strong adsorption exhibited by step and {100} terrace sites with only weak interactions observed between PVP and Pt{111...

The vibrational spectra of platinum nanoparticles (2.4-9 nm) capped with poly(N-vinylpyrrolidone) (PVP) were investigated by deep UV-Raman and FTIR spectroscopy and compared with those of pure PVP. Raman spectra of PVP/Pt show selective enhancement of C=O, C-N, and CH2 vibrational modes attributed to the pyrrolidone ring. Selective enhancement of ring vibrations is attributed both to the resona...

T cells from CAF1 mice immunized with various amounts of the type 2 antigen polyvinylpyrrolidone (PVP) were assessed for their ability to provide help to PVP-specific memory B cells for the production of IgG. Low doses (0.0025 micrograms) of PVP consistently activated helper T cells (Th), which were required for the production of IgG by primed B cells. In contrast, T cells from mice primed with...

The effect of solvent power and flow rate on the permeability of a size exclusion chromatography (SEC) column packed with a novel polyvinylpyrrolidone (PVP)-grafted porous silica resin was studied. The PVP-silica resin was prepared from a porous silica size exclusion resin onto which a terminally anchored PVP layer was graft polymerized. The terminally anchored PVP layer was synthesized via a f...

OBJECTIVE Percutaneous vertebroplasty (PVP) is an effective treatment modality for management of osteoporotic compression fracture. However physicians sometimes have problems of high pressure in cement delivery and cement leakage when using Jamshidi® needle (JN). Bone void filler (BVF) has larger lumen which may possibly diminish these problems. This study aims to compare the radiologic and cli...