Objective(s) The purpose of this study was to investigate the role of oxidative stress in Purkinje cell neurotoxicity ofethanol-treated rat. Materials and Methods Male rat pups 4-day-old was used in this study. Ethanol was administered to rat pups at a dose of 6 g/kg from postnatal days (PDs) 4 to 5.  Pups were killed 90 min after the second alcohol treatment on PD 5 by decapitation and the ...

objective(s) the purpose of this study was to investigate the role of oxidative stress in purkinje cell neurotoxicity ofethanol-treated rat. materials and methods male rat pups 4-day-old was used in this study. ethanol was administered to rat pups at a dose of 6 g/kg from postnatal days (pds) 4 to 5.  pups were killed 90 min after the second alcohol treatment on pd 5 by decapitation and the bra...

Introduction: Diabetes mellitus is associated with nervous system alterations in both human and animal models. This study was done to determine the effect of gestational diabetes on the Purkinje and granular cells in the cerebellum of rat offspring.  Methods: 10 Wistar rats Dams were randomly allocated in control and diabetic group. The experimental group received 40 mg/kg/body wei...

We report on a rare case of paraneoplastic syndrome (PS) that was discovered completion diagnostic work up to be fallopian tube carcinoma. A 65year old female, presented with 1 month history imbalance, gait instability, incoordination right upper limb, vertigo and vomiting. Cerebrovascular accident drug intoxication excluded. Indicative further diagnosis presence adnexal mass in pelvis identifi...

Activation of the parasympathetic nervous system has been reported to have an antiarrhythmic role during ischemia–reperfusion injury by decreasing arrhythmia triggers. Furthermore, it was that neurotransmitter acetylcholine is able modulate ATP-dependent potassium current (I K-ATP ), a crucial activated hypoxia. However, possible significance this modulation in mechanism not fully clarified. Ac...

introduction: diabetes mellitus is associated with nervous system alterations in both human and animal models. this study was done to determine the effect of gestational diabetes on the purkinje and granular cells in the cerebellum of rat offspring.  methods: 10 wistar rats dams were randomly allocated in control and diabetic group. the experimental group received 40 mg/kg/body weight of strept...

Structural changes in Purkinje cells have been identified in the essential tremor cerebellum, although the mechanisms that underlie these changes remain poorly understood. Climbing fibres provide one of the major excitatory inputs to Purkinje cells, and climbing fibre-Purkinje cell connections are essential for normal cerebellar-mediated motor control. The distribution of climbing fibre-Purkinj...

background: learning and memory are the most intensively studied subjects in neuroscience. two sites of mammalian brain which are important in learning and memory are ca1 region of hippocampus and purkinje cell layer of cerebellum. so, the aim of present investigation was to study of the effect of ovariectomy and passive avoidance learning on nr1 subunit of n-methyl-d-aspartate (nmda) receptor ...

Here, we show that cultured Purkinje cells from inositol 1,4,5-trisphosphate receptor type 1 knock-out (IP3R1KO) mice exhibited abnormal dendritic morphology. Interestingly, despite the huge amount of IP3R1 expression in Purkinje cells, IP3R1 in granule cells, not in the Purkinje cells, was responsible for the shape of Purkinje cell dendrites. We also found that BDNF application rescued the den...