Adenosine has been implicated in the pathogenesis of chronic lung diseases such as asthma and chronic obstructive pulmonary disease. In vitro studies suggest that activation of the A2B adenosine receptor (A2BAR) results in proinflammatory and profibrotic effects relevant to the progression of lung diseases; however, in vivo data supporting these observations are lacking. Adenosine deaminase-def...

conclusions results of the present study showed that hydroalcoholic extracts of pomegranate seeds had a significant protective effect against bleomycin-induced lung fibrosis by its antioxidant properties. the highest protective effect was observed for the 400 mg/kg dose. results histological analysis showed that pse could prevent pathological changes that were seen in the bleomycin group. objec...

The development of pulmonary fibrosis is the end point of a wide range of respiratory diseases including organic and inorganic dust exposure, pulmonary infection, acute lung injury, radiation, the idiopathic interstitial pneumonias (IIP), and connective tissue diseases. The most common fibrotic lung disorder is idiopathic pulmonary fibrosis (IPF), an IIP with the histological appearance of usua...

BACKGROUND Despite intense research efforts, the aetiology and pathogenesis of idiopathic pulmonary fibrosis remain poorly understood. Gelsolin, an actin-binding protein that modulates cytoskeletal dynamics, was recently highlighted as a likely disease modifier through comparative expression profiling and target prioritisation. METHODS To decipher the possible role of gelsolin in pulmonary in...

background since tuberculosis (tb) is a major public health problem that is a leading cause of mortality and morbidity among infectious diseases worldwide, early diagnosis and treatment are important to control an effective tuberculosis (tb) and also the increasing number of patients with atypical manifestations of active tb. it suggests more evaluation for active tb in fibrotic lesion in ct sc...

Citation: Eisenhut M (2017) Commentary: Cytokine-Regulation of Na+-K+-Cl− Cotransporter 1 and Cystic Fibrosis Transmembrane Conductance Regulator-Potential Role in Pulmonary Inflammation and Edema Formation. Front. Immunol. 8:1490. doi: 10.3389/fimmu.2017.01490 Commentary: Cytokine-regulation of na+-K+-Cl− Cotransporter 1 and Cystic Fibrosis transmembrane Conductance regulator-Potential role in...

Pulmonary fibrosis is a devastating, incurable disease in which chronic inflammation and dysregulated, excessive wound healing lead to progressive fibrosis, lung dysfunction, and ultimately death. Prior studies have implicated the cytokine IL-17A and Th17 cells in promoting the development of fibrosis. We hypothesized that loss of Th17 cells via CD4-specific deletion of mTORC1 activity would ab...

Pulmonary fibrosis is an end-stage disorder for which efficacious therapeutic options are not readily available. Although its pathogenesis is poorly understood, pulmonary fibrosis occurs as a result of various inflammations. NKT cells modulate inflammation because of their ability to produce large amounts of cytokines by stimulation with their glycolipid ligand. In the present study, we investi...

Lung disorders induced by inhaled inorganic particles such as crystalline silica are characterized by chronic inflammation and pulmonary fibrosis. Here, we demonstrate the importance of type I interferon (IFN) in the development of crystalline silica-induced lung inflammation in mice, revealing that viruses and inorganic particles share similar signaling pathways. We found that instillation of ...

Sphingolipids and in particular ceramide have been shown to be critically involved in the response to many receptor-mediated, but also receptor-independent, mainly stress stimuli. Recent studies demonstrate that ceramide plays an important role in the pathogenesis of cystic fibrosis, a hereditary metabolic disorder caused by mutations of the Cystic Fibrosis Transmembrane Conductance Regulator. ...