Using cell lines and primary cells, it has been shown that translation control plays a key role regulating gene expression during physiological and pathological conditions. The relevance of this type of regulation in vivo (tissues, organs) remains to be elucidated, due to the lack of an efficient method for polysome-bound fractionation of solid tissue RNA samples. A simple and efficient method ...

Regulatory regions within the 3' untranslated region (UTR) influence polyadenylation (polyA), translation efficiency, localization and stability of mRNA. Alternative polyA (APA) has been considered to have a key role in gene regulation since 2008. Esophageal carcinoma is the eighth most common type of cancer worldwide. The association between polyA and disease highlights the requirement for com...

Microarray gene expression profiling studies have demonstrated immune response gene signatures that appear predictive of outcome in follicular lymphoma (FL). However, measurement of these marker genes in routine practice remains difficult. We have therefore investigated the immune response in FL using real-time polymerase chain reaction (PCR) to measure expression levels of 35 candidate Indicat...

For noninformative nonparametric estimation of finite population quantiles under simple random sampling, estimation based on the Polya posterior is similar to estimation based on the Bayesian approach developed by Ericson (1969, JRSSB, 31, 195-233) in that the Polya posterior distribution is the limit of Ericson’s posterior distributions as the weight placed on the prior distribution diminishes...

The Performance of the Viterbi algorithm with a new Polya contagion noise process is analyzed. The markov channel is the memory channel usually studied in the bibliography. The Polya channel was introduced years ago as a special case of a memory channel. In this work, the Polya contagion scheme is considered as a noise process and a GaussPolya noise model is introduced this way in order to perf...

A separated sequence Λ on the real line is called a Polya sequence if any entire function of zero exponential type bounded on Λ is constant. In this paper we solve the problem by Polya and Levinson that asks for a description of Polya sets. We also show that the Polya-Levinson problem is equivalent to a version of the so-called Beurling gap problem on Fourier transforms of measures. The solutio...

Genes containing multiple pre-mRNA cleavage and polyadenylation sites, or polyA sites, express mRNA isoforms with variable 3' untranslated regions (UTRs). By systematic analysis of human and mouse transcriptomes, we found that short 3'UTR isoforms are relatively more abundant when genes are highly expressed whereas long 3'UTR isoforms are relatively more abundant when genes are lowly expressed....

RNA transcripts are generally classified into polyA-plus and polyA-minus subgroups due to the presence or absence of a polyA tail at the 3' end. Even though a number of physiologically and pathologically important polyA-minus RNAs have been recently identified, a systematic analysis of the expression and function of these transcripts in adipogenesis is still elusive. To study the potential func...

Long-lasting changes in synaptic functions after an appropriate stimulus require altered protein expression at the synapse. To restrict changes in protein composition to activated synapses, proteins may be synthesized locally as a result of transmitter receptor-triggered signaling pathways. Second messenger-controlled mechanisms that affect mRNA translation are essentially unknown. Here we repo...

Previous type systems for mobility calculi (the original Mobile Ambients, its variants and descendants, e.g., Boxed Ambients and Safe Ambients, and other related systems) offer little support for generic mobile agents. Previous systems either do not handle communication at all or globally assign fixed communication types to ambient names that do not change as an ambient moves around or interact...