Abstract 10-Methyl-aplog-1 (1), a simplified analog of debromoaplysiatoxin, exhibits high binding affinity for protein kinase C (PKC) isozymes and potent antiproliferative activity against several cancer cells with few adverse effects. A recent study has suggested that its phenol group in the side chain is involved hydrogen bonding CH/? interactions cleft-forming loops PKC?-C1B domain. To clari...

patients with diabetes mellitus (dm), experience significant morbidity and mortality from microvascular retinopathy, nephropathy and neuropathy. hyperglycemia can induce diabetic complications through multiple pathways. activation of protein kinase c (pkc) by hyperglycemia is one of the pathways which causes diabetic complications. effect of nifedipine (a calcium channel blocker), and polymyxin...

Abstract MCP-1–induced monocyte chemotaxis is a crucial event in inflammation and atherogenesis. Identifying the important signal transduction pathways that control can unravel potential targets for preventive therapies inflammatory disease conditions. Previous studies have shown focal adhesion kinase Pyk2 plays critical role motility. In this study, we investigated MCP-1–mediated activation of...

Certificateless Public Key Cryptography (CL-PKC) scheme is a new standard that combines Identity (ID)-based cryptography and tradi- tional PKC. It yields better security than the ID-based without requiring digital certificates. In CL-PKC scheme, as Generation Center (KGC) generates public key using partial secret key, need for authenticating by trusted third party avoided. Due to lack of authen...

ABSTRACT Fertilization triggers significant cellular remodeling through the oocyte-to-embryo transition. In this transition, ubiquitin-proteasome system and autophagy are essential for degradation of maternal components; however, significance cell surface components remains unknown. study, we show that multiple plasma membrane proteins, such as glycine transporter GlyT1a, selectively internaliz...

Background: Our previous findings indicated that carvacrol and thymol alleviate cognitive impairments caused by Aβ in rodent models of Alzheimer's disease (AD). In this study, the neuroprotective effects of carvacrol and thymol against Aβ25-35-induced cytotoxicity were evaluated, and the potential mechanisms were determined. Methods: PC12 cells were pretreated with Aβ25-35 for 2 h, followed by ...

Background: Tolerance and dependence to anti-nociceptive effect of morphine restricted its use. Nowadays co-administration of morphine and other drugs suggests diminishing this tolerance. Baclofen is one of the drugs that may be beneficial in the attenuation of tolerance to morphine. Studies have shown that changes in transient receptor potential vanilloid type 1 (TRPV-1) expression during admi...

Severe acute respiratory syndrome (SARS) coronavirus (CoV) 2 (SARS-CoV-2), which causes the disease 2019, encodes several proteins whose roles are poorly understood. We tested their ability either to directly form plasma membrane ion channels or change functions of two mammalian channels, epithelial sodium channel (ENaC) and ?3?4 nicotinic acetylcholine receptor. In mRNA-injected Xenopus oocyte...

Palm kernel cake (PKC) is a nutrient-rich by-product of oil mills that contained high concentration copper (Cu) among other minerals elements. The higher dietary Cu was reported to impair some physiological functions in breeds sheep due toxicity. Hence, this study aimed investigate the histopathological effects PKC based diet on vital organs Dorper lambs. Fifteen male lambs (8 month-old) were r...