Aging, as a major risk factor of memory deficiency, affects neural signaling pathways in hippocampus. In particular, age-dependent androgens deficiency causes cognitive impairments. Several enzymes like protein kinase C (PKC) are involved in memory deficiency. Indeed, PKC regulatory process mediates α-secretase activation to cleave APP in β-amyloid cascade and tau proteins phosphorylation mecha...

Introduction: Transient receptor potential vanilloid type 1 (TRPV1) and protein kinase Cγ (PKCγ) are involved in sensitization/desensitization to noxious stimuli. We aimed to examine the gene expression levels of TRPV1 and PKCγ in rat lumbosacral cord and midbrain on days 1, 4 and 8 of induction of morphine analgesic tolerance. Methods: Two groups of male Wistar rats received ...

The research is to find out the level starbio in palm kernel cake (PKC) on energy and protein use chicks. chemical analysis was done Quality Certification Feed Laboratory Bekasi, West Java. experiment composed by five treatments i.e. dose of (g/kg PKC) with level: 0%;0,25%; 0,5%; 0,75%; 1%; for PO;P1:P2:P3; P4, respectively. variables were observed apparent metabolizable (AME), digestibility, n...

Objective(s): Pathophysiology of sepsis-associated renal failure (one of the most common cause of death in intensive care units) had not been fully determined. The effect of nitric oxide and protein kinase C (PKC) pathways in isolated kidney of Lipopolysaccharide-treated (LPS) rats were investigated in this study. Materials and Methods: Vascular responsiveness to phenylephrine and acetylcholine...

background: neutrophils have an important role in the rapid innate immune response, and the release or active secretion of elastase from neutrophils is linked to various inflammatory responses. purpose of this study was to determine how the human neutrophil elastase affects the interleukin-10 (il-10) response in peripheral blood mononuclear cells (pbmc). materials and methods: in this prospecti...

Abstract L-type amino acid transporter 2 (LAT2) is a Na + -independent neutral transporter, whose function regulation system remains unclarified. Since protein kinase C (PKC) known to regulate the functions of various transporters, we investigated whether human LAT2 (hLAT2) regulated by PKC. In mouse proximal tubule S2 cells, hLAT2 transport activity was upregulated PKC activation. However, fou...

Abstract During cancer and chronic viral infections, the persistence of antigen progressively causes CD8+ T cells to differentiate into a dysfunctional PD1+ “exhausted” state, with reduced production inflammatory cytokines relative effector that form during acute infections. Antigen costimulation signals activate kinase cascades induce distinct cell transcription programs, but how distinguish p...

SUMMARYPalm kernel cake (PKC) is a by-product of oil extraction from palm fruits and has been included in poultry diets as an alternative to soybean meal yellow corn. Due its high content fibre, coarse texture gritty appearance, the use PKC nutrition limited. In order increase nutritive value PKC, there tendency nowadays create solid state fermentation (SSF) by using cellulolytic microbes. This...

Background: For understanding the roles of fatty acids on the induction of acrosome reaction which occurs under association of cholesterol efflux and PKA or PKC pathways in boar spermatozoa, metabolic fate of alone and combined radiolabeled 14C-oleic acid and 3H-linoleic acid incorporated in the sperm was compared, and behavior of cholesterol and effects of PKA and PKC inhibitors upon fatty aci...

objective(s): protein kinase c (pkcα) is involved in modulating articular chondrocytes apoptosis induced by nitric oxide (no). hyaluronic acid (ha) inhibits nitric oxide-induced apoptosis of articular chondrocytes by protecting pkcα, but the mechanism remains unclear. the present study was performed to investigate the effects and mechanisms of pkcα regulate protective effect of hyaluronic acid....