The external treatment of seborrheic dermatitis the scalp depends on withdrawal clinical symptoms and complaints patient made to doctor. At present Ukrainian dermatology has several dozen pharmacotherapeutic products in this direction, with dominating medicines ketoconazole, zinc pyrition, their combinations. They are characterized by short-term or weak effect, associated pathogenic microorgani...

Hair shedding and hair thinning have been reported to be affected by dandruff and seborrhoeic dermatitis. The present study was conducted in 150 men presenting with telogen effluvium related to androgenic alopecia associated with dandruff. They were randomly allocated to three groups receiving each one of the three shampoos in the market containing either 1% ketoconazole (KTZ), 1% piroctone ola...

Malassezia spp in skin microbiome scalp has been implicated in seborrheic dermatitis pathogenesis. Thus, treatment based in antifungal combined to topical keratolitic agents have been indicated as well as oral isotretinoin as it reduces the sebum production, glandular's size and possesses anti-inflammatory properties. This randomized, comparative and therapeutic trial aimed toper form the genot...

Hypertrophic scars are a common complication of burn injury, yet there no medications to prevent their formation. Myofibroblasts, key cell involved in scar formation, resistant apoptosis. We have previously shown that hydroxypyridone anti-fungals can inhibit myofibroblast transformation scar-derived fibroblasts. This study aimed investigate if these drugs target established myofibroblasts. Prim...

OBJECTIVES The aim of this study was to identify changes in the gene expression profile of Candida albicans upon exposure to the hydroxypyridone anti-infective agent ciclopirox olamine in an effort to better understand its mechanism of action. METHODS C. albicans SC5314 was exposed to either medium alone or ciclopirox olamine at a concentration equivalent to the IC50 (0.24 mg/L) for 3 h. RNA ...

The hydroxypyridone ciclopirox olamine belongs to the antimycotic drugs used for the treatment of superficial mycoses. In contrast to the azoles and other antimycotic drugs, its specific mode of action is only poorly understood. To investigate the mode of action of ciclopirox olamine on fungal viability, pathogenicity, and drug resistance, we examined the expression patterns of 47 Candida albic...