Abstract A radical α−C−H alkylation of a collection N ‐picolinamide amino acid derivatives with ethers and cycloalkanes as chemical feedstock is described. This cross‐dehydrogenative coupling distinguished by its reliable scalability removable auxiliary group, enables the assembly variety tri‐ tetrasubstituted compounds. magnified image

In the title compound, [Ni(C(26)H(20)N(4)O(2))]·0.5C(4)H(10)O, the central metal ion is coordinated by four atoms of the tetra-dentate picolinamide ligand, forming a slightly distorted square-planar configuration, with an average Ni-N(pyridine) distance of 1.94 Å and an average Ni-N(amide) distance of 1.83 Å. The asymmetric unit contains one half-molecule of diethyl ether; this solvent molecule...

In the title compound, C(12)H(7)Cl(2)FN(2)O, the dihedral angle between the phenyl and pyridine rings is 42.5 (2) Å and an intramolecular N-H⋯N hydrogen bond occurs. The crystal structure is stabilized by C-H⋯O, C-H⋯F and C-Cl short contacts.

[Cp*IrLnCl] complexes [L1 = (methyl-β-d-glucopyranosid-2-yl)picolinamide, 1; L2 (methyl-3,4,6-tri-O-acetyl-β-d-glucopyranosid-2-yl)picolinamide, 2; L3 (2,3,4,6-tetra-O-acetyl-β-d-glucopyranosid-1-yl)picolinamide, 3] have been synthesized and completely characterized in solution, by 1D- 2D-NMR spectroscopy, the solid state, X-ray single crystal diffractometry. Despite chirality of Ln-moiety meta...

Streptozotocin and alloxan were administered to Wistar rats in combination with poly(adenosine diphosphate ribose) synthetase inhibitors. Ten to 16 months after the injection of streptozotocin (50 mg/kg body weight i.v.) and 3-aminobenzamide (345 mg/kg i.v.), streptozotocin (50 mg/kg) and nicotinamide (350 mg/kg i.p.), streptozotocin (50 mg/kg) and picolinamide (250 mg/kg i.p.), alloxan (40 mg/...

Abstract We report the application of Pd(II)-catalyzed, directing-group-aided C–H arylation/alkylation tactics to functionalize pyrene core, especially, relatively inaccessible C2 and K-region C10 positions core augmentation library derivatives with C1,C2- C1,C10-disubstituted motifs. The Pd(II)-catalyzed β-C–H C2-position pyrene-1-carboxamide possessing an 8-aminoquinoline directing group yiel...

This work presents the synthesis of eight new rhodium(III) dihalido complexes, [RhX2(L)(LH)] (where X = Cl or I), which incorporate two bidentate N-(3-halidophenyl)picolinamide ligands. The ligands have different binding modes in whereby one is neutral and bound via N,N (LH) coordination, while other anionic N,O (L) coordination. solid state solution studies confirm multiple isomers are present...