Film coating is an essential unit operation in tablet manufacturing. Most tablet dosage forms in the market are film coated. The main purpose for coating of immediate release film dosage form is to provide colour identification, to enhance the stability, taste masking. It is also noted that film coating can improve the processibility and handling during pharmaceutical manufacturing and is the m...

This paper describes a collaborative theoretical and experimental research effort to investigate the performance of co-axial atomizers utilized in pharmaceutical tablet coating when atomizing common tablet coating solutions under typical processing conditions. In pharmaceutically relevant applications, the liquids being atomized are typically complex, non-Newtonian fluids which may contain poly...

We present terahertz pulsed imaging (TPI) as a novel tool to quantify the hardness and surface density distribution of pharmaceutical tablets. Good agreement between the surface refractive index (SRI) measured by TPI and the crushing force measured from diametral compression tests was found using a set of tablets that were compacted at various compression forces. We also found a strong correlat...

The dissolution characteristics of pharmaceutical tablets are key to determining the bioavailability of the active pharmaceutical ingredient (API) and it is therefore vital to understand the physical processes that affect drug release. As well as the API, tablets also consist of a supporting polymer matrix (known as the excipient) and other compounds such as fillers, binders, lubricants etc. Th...

Bilayered tablet is an important pharmaceutical technology for the successful development of controlled release formulation along with various features to provide a way of successful drug delivery system. Bi-layer tablet is suitable for sequential release of two drugs in combination, to separate incompatible substances and also formulating sustained release tablet in which one layer is immediat...

The pharmaceutical properties of clarithromycin (CAM) tablets containing the metastable form I of crystalline CAM were investigated. Although the dissolution rate of form I was higher than that of stable form II, the release of CAM from form I tablet was delayed. Disintegration test and liquid penetration test showed that the disintegration of the tablet delayed because of the slow penetration ...

The manufacture of bi-layer tablets, produced by the sequential compaction of loose powder layers has recently become of increased interest within the pharmaceutical industry due to the tailored release profiles of active ingredients that may be obtained. In a bi-layer configuration, the immediate release layer of the bilayer tablet has worked as the loading dose and the sustained release layer...

A multivariate statistical technique was applied to the design of an orally disintegrating tablet and to clarify the causal correlation among variables of the manufacturing process and pharmaceutical responses. Orally disintegrating tablets (ODTs) composed mainly of mannitol were prepared via the wet-granulation method using crystal transition from the δ to the β form of mannitol. Process param...

28 29 The pharmacokinetics of raltegravir (RAL) in HIV patients is characterised by high 30 inter/intra-patient variability. We investigated the potential contribution of the drug 31 pharmaceutical formulation on RAL pharmacokinetics. 32 We firstly compared in vivo the pharmacokinetics of RAL from 67 patients in which 33 the drug was administered by swallowing the intact tablet with those obtai...

Due to various advantages such as high-precision dosing, manufacturing efficiency and patient compliance helped making tablets the most popular dosage forms among all available dosages forms. Compaction, which is an essential manufacturing step in the manufacture of tablets, mainly includes compression (i.e. reduction of volume of the powder under consideration and particle rearrangement) and c...