نتایج جستجو برای: ph sensitive nanoparticles

تعداد نتایج: 539402  

Journal: :Chemical communications 2015
Zeng-Ying Qiao Chun-Yuan Hou Wen-Jing Zhao Di Zhang Pei-Pei Yang Lei Wang Hao Wang

The bis(pyrene) conjugated pH-sensitive polymers () were synthesized and self-assembled into nanoparticles through hydrophobic interactions. The Nile red (NR) loaded nanoparticles showed red emission due to the FRET effect. The nanoparticles entered cells via endocytosis, and the microenvironmental pH in the endocytosis process was monitored in situ by the simultaneous dual-wavelength fluoresce...

2016
Yongjiu Lv Lan Hao Wenjing Hu Ya Ran Yan Bai Liangke Zhang

This study fabricated novel multifunctional pH-sensitive nanoparticles loaded into microbubbles (PNP-MB) with the combined advantages of two excellent drug delivery vehicles, namely, pH-sensitive nanoparticles and microbubbles. As an antitumor drug, resveratrol (RES) was loaded into acetylated β-cyclodextrin nanoparticles (RES-PNP). The drug-loaded nanoparticles were then encapsulated into the ...

Journal: :Frontiers in bioscience : a journal and virtual library 2005
Jia-Shen Wei Hong-Bo Zeng Shao-Qiong Liu Xiao-Gong Wang Eng Hock Tay Yi-Yan Yang

Temperature- and pH-sensitive amphiphilic polymer poly(N-isopropylacrylamide-co-acrylic acid-co-cholesteryl acrylate) (P(NIPAAm-co-AA-co-CHA)) has been synthesized and employed to encapsulate paclitaxel, a highly hydrophobic anticancer drug, in core-shell nanoparticles fabricated by a membrane dialysis method. The nanoparticles are spherical in shape, and their size can be made below 200 nm by ...

2012
Rong Liu Bin He Dong Li Yusi Lai Jing Chang James Z Tang Zhongwei Gu

BACKGROUND Two methoxyl poly(ethylene glycol)-poly(L-histidine)-poly(L-lactide) (mPEG-PH-PLLA) triblock copolymers with different poly(L-histidine) chain lengths were synthesized. The morphology and biocompatibility of these self-assembled nanoparticles was investigated. METHODS Doxorubicin, an antitumor drug, was trapped in the nanoparticles to explore their drug-release behavior. The drug-l...

2015
Manuel Häuser Klaus Langer Monika Schönhoff

Nanoparticles (NP) of poly(lactic-co-glycolic acid) (PLGA) represent a promising biodegradable drug delivery system. We suggest here a two-step release system of PLGA nanoparticles with a pH-tunable polymeric shell, providing an initial pH-triggered step, releasing a membrane-toxic cationic compound. PLGA nanoparticles are coated by polyelectrolytes using the layer-by-layer self-assembly techni...

Elham Khodaverdi, Mohammad Abdekhodai Omid Rajabi Xiao Yu Wu

Objective(s) In this study, a kind of pH sensitive composite membrane was prepared and drug permeation through it was investigated in terms of pH. Rationale of this study originated from the fact that a pH change which may be a result of a disease state in the body can trigger drug release. Materials and Methods  Here, a kind of pH sensitive composite membrane containing different nanoparticle ...

2009
Mikhail Y. Berezin Kevin Guo Hyeran Lee Walter Akers Adah Almutairi Jean M.J. Fréchet Samuel Achilefu

Many physiological processes function efficiently within a well-controlled pH range. Higher acidity level has been implicated with a number of systemic pathologies. The potential of pH sensitive fluorescent probes for reporting on biological environments has been widely utilized in a variety of cell studies and has been recently recognized as a powerful technique for in vivo imaging of diseases...

Journal: :Nanotechnology 2009
Dhananjay Thakur Shuang Deng Thierno Baldet Jessica O Winter

There has been great interest in the use of nanoparticles for imaging, particularly in multimodal applications (e.g., combination of MRI and fluorescence). Yet creating particles with multiple functionalities has been challenging. Here, we report the synthesis of pH sensitive, fluorescent-magnetic, nanocomposites created through a simple aqueous procedure. Separately synthesized superparamagnet...

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