This study aimed to examine differences in CVD risk factors across four crosstabulated groups according to health-related physical fitness index (PFI, composite index of standing long jump, 50-m test, and 800or 1000-m run/walk) and waist circumference (WC) in Guangzhou youth. Participants comprised 588 males and 579 females aged 11–18 years from Guangzhou, China. They were cross-tabulated into ...

The Private Finance Initiative (PFI) in the U.K. has been the subject of considerable interest in government, professional and academic literature. This reflects its importance as one of the classic forms of Public Private Partnership, its adoption in other jurisdictions, the scale of infrastructure investment under PFI legislation and the extent of controversy that has accompanied its developm...

SET domain containing (lysine methyltransferase) 7 (SETD7) is implicated in multiple signaling and disease related pathways with a broad diversity of reported substrates. Here, we report the discovery of (R)-PFI-2-a first-in-class, potent (Ki (app) = 0.33 nM), selective, and cell-active inhibitor of the methyltransferase activity of human SETD7-and its 500-fold less active enantiomer, (S)-PFI-2...

Inference in the presence of non-ignorable missing data is a widely encountered and difficult problem in statistics. Imputation is often used to facilitate parameter estimation, which allows one to use the complete sample estimators on the imputed data set. We develop a parametric fractional imputation (PFI) method proposed by Kim (2011), which simplifies the computation associated with the EM ...

In Japan, the development and financing of infrastructure are traditionally dominated by the public sector. Learning from the failures of so called ‘‘third sector’’ projects in the 1970s and 1980s as well as based on experience from the Private Finance Initiative (PFI) in other countries, Japan introduced a PFI Promotion Law in 1999 to enhance private participation in the provision of infrastru...

INTRODUCTION The Fatigue Assessment Scale (FAS) is a 10-item patient reported outcome (PRO) questionnaire that is used to measure fatigue in sarcoidosis. After several months of use, we began to question the reliability of the FAS in our clinic population. Therefore, we administered an additional fatigue PRO, the Patient Reported Outcomes Measurement Information Systems (PROMIS) Fatigue Instrum...

OBJECTIVE The objective of this study was to evaluate the performance of the Professional Fulfillment Index (PFI), a 16-item instrument to assess physicians' professional fulfillment and burnout, designed for sensitivity to change attributable to interventions or other factors affecting physician well-being. METHODS A sample of 250 physicians completed the PFI, a measure of self-reported medi...

BACKGROUND The biological risk factors of inactivity and poor cardiorespiratory fitness are well established. However, risk groups are hard to reach and they may have misperceptions of their need for change. This study explored self-ratings of physical fitness (PF) and the relationship between objectively estimated physical fitness (PFI) and psychosocial factors among Finnish men of working-age...

Wide surgical resection or a marginal/incomplete resection followed by full-course radiation therapy is the current standard of care for canine soft tissue sarcoma. The purpose of this retrospective, descriptive, bi-institutional study was to determine the effectiveness and toxicity of a hypofractionated 5 × 6 Gy protocol on macroscopic canine soft tissue sarcoma in terms of progression-free in...

The Internal Rate of Return (IRR) is a commonly used indicator of the performance of Private Finance Initiative (PFI), schemes in the UK. Treasury guidance recognises, however, that IRR is potentially misleading, unless the relevant payment streams are of a flat, annuity, type. This paper uses data on a number of actual PFI schemes to examine whether the payment streams involved are sufficientl...