BACKGROUND Pantoprazole sodium, a proton-pump inhibitor, is approved for the short-term treatment of several types of ulcer, Zollinger-Ellison syndrome, and gastroesophageal reflux disease. OBJECTIVE To determine the physical compatibility and chemical stability of ethylenediaminetetra-acetic acid (EDTA)-free pantoprazole in glass vials, polypropylene syringes, and polyvinylchloride (PVC) min...

OD-PEP (a Fixed dose combination of Pantoprazole and Domperidone) contains Pantoprazole which is chemically sodium 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2pyridinyl)methyl]sulfinyl]-1H-benzimidazole sesquihydrate and Domperidone which is chemically 5-chloro-1-[1-[3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl]-piperidin-4 -yl]1,3-dihydro-2H-benzimidazol-2-one. OD-PEP capsule is Transparent/Tr...

Two simple, rapid and accurate conductometric methods were developed for determination of losartan potassium, pantoprazole sodium, sumatriptan succinate, rabeprazole sodium and lomefloxacine HCl in pure form as well as in their pharmaceutical formulations. The proposed methods based on using two different precipitating agents for conductometric determination of the cited drugs. Method (A) based...

The objective of this study was to investigate the bioequivalence of two formulations of 40 mg pantoprazole sodium enteric-coated tablets: Tripepsa as the test and Pantocid as the reference. The two products were administered as a single oral dose according to a randomized two-phase crossover with a 1-month washout period in 25 healthy Indian volunteers. After drug administration, serial blood ...

A specific, precise and stability indicating high-performance thin-layer chromatographic method for simultaneous estimation of pantoprazole sodium and itopride hydrochloride in pharmaceutical formulations was developed and validated. The method employed TLC aluminium plates precoated with silica gel 60F254 as the stationary phase. The solvent system consisted of methanol:water:ammonium acetate;...

Two modified coated membrane sensors were designed and tested. Pantoprazole-phosphotungstate was prepared by a reaction of pantoprazole with phosphotungstic acid in the solvent mediator o-nitrophenyloctyl ether. metal oxide nanoparticles nickel iron nanoparticles, synthesized from green sources Matricaria recutita flowers Salvia officinalis leaves extracts, respectively. These used for potentio...

We tested the hypothesis that the stable isotope [(13)C]pantoprazole is O-demethylated by cytochrome P450 CYP2C19 and that the (13)CO(2) produced and exhaled in breath as a result can serve as a safe, rapid, and noninvasive phenotyping marker of CYP2C19 activity in vivo. Healthy volunteers who had been genotyped for the CYP2C19(*)2, CYP2C19(*)3, and CYP2C19(*)17 alleles were administered a sing...

The aim of the present work was to verify the in vivo capacity of pantoprazole-loaded microparticles to protect the gastric mucosa against ulcer formation and to evaluate their stability under accelerated conditions. Pantoprazoleloaded microparticles were prepared by spray-drying in pilot scale, using Eudragit ® S100 as polymer. Transparent glass vials containing drug-loaded microparticles were...

Six impurities in pantoprazole sodium bulk drug substance were detected by a simple high performance liquid chromatographic method (HPLC) whose area percentage ranged from approximately 0.05 to 0.34%. Liquid chromatography-mass spectrometry (LC-MS) was performed to identify the molecular weight of the impurities. A thorough study was undertaken to characterize these impurities. These impurities...

Hyponatremia is the most common electrolyte balance disorder, especially in the elderly and polymedicated population. The authors report the case of an 83-year-old man with symptomatic severe hyponatremia due to Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) related to pantoprazole. Pantoprazole was discontinued and serum sodium levels reached normal values in two months. To t...