نتایج جستجو برای: p5 peptide

تعداد نتایج: 161329  

2012
Manling Zhang Eiki Takimoto Taishi Nakamura Takahiro Nagayama Ajay M. Shah

Background—In the normal heart, phosphodiesterase type 5 (PDE5) hydrolyzes cGMP coupled to nitric oxide– (specifically from nitric oxide synthase 3) but not natriuretic peptide (NP)–stimulated guanylyl cyclase. PDE5 is upregulated in hypertrophied and failing hearts and is thought to contribute to their pathophysiology. Because nitric oxide signaling declines whereas NP-derived cGMP rises in su...

Journal: :Circulation 2012
Manling Zhang Eiki Takimoto Dong-ik Lee Celio X C Santos Taishi Nakamura Steven Hsu Aiyang Jiang Takahiro Nagayama Djahida Bedja Yuan Yuan Philip Eaton Ajay M Shah David A Kass

BACKGROUND In the normal heart, phosphodiesterase type 5 (PDE5) hydrolyzes cGMP coupled to nitric oxide- (specifically from nitric oxide synthase 3) but not natriuretic peptide (NP)-stimulated guanylyl cyclase. PDE5 is upregulated in hypertrophied and failing hearts and is thought to contribute to their pathophysiology. Because nitric oxide signaling declines whereas NP-derived cGMP rises in su...

Journal: :Blood 1991
M R Fibi W Stüber P Hintz-Obertreis G Lüben D Krumwieh B Siebold G Zettlmeissl H A Küpper

Five different peptides (P1: 84-95; P2: 152-166; P3: 52-63; P4: 7-23; P5: 110-123) homologous to relatively hydrophilic regions of human erythropoietin (huEpo) have been synthesized to identify biologically active domains of the hormone. All peptides were able to induce high titers of peptide-specific antibodies in rabbits. Antisera from rabbits induced by recombinant huEpo (rhuEpo) contained a...

2016
Min-Young Kim Woon-Dong Cho Kwon Pyo Hong Da Bin Choi Jeong won Hong Soseul Kim Yoo Ri Moon Seung-Myoung Son Ok-Jun Lee Ho-Chang Lee Hyung Geun Song

The use of anti-beta 1 integrin monoclonal antibody in lung cancer treatment has proven beneficial. Here, we developed a novel monoclonal antibody (mAb), called P5, by immunizing mice with human peripheral blood mononuclear cells (PBMC). Its anti-tumor effect is now being tested, in a clinical phase III trial, in combinatorial treatments with various chemical drugs. To confirm that P5 indeed bi...

Journal: :Diabetes 2001
O O Oluwole H A Depaz R Gopinathan A Ali M Garrovillo M X Jin M A Hardy S F Oluwole

Pancreatic islet transplantation remains a promising approach to the treatment of type 1 diabetes. Unfortunately, graft failure continues to occur because of immunologic rejection, despite the use of potent immunosuppressive agents. It is therefore reasoned that induction of peripheral tolerance by the use of self-dendritic cells (DCs) as a vehicle to deliver specific target antigens to self-T-...

Journal: :Endocrinology 2013
Olivier Brock Julie Bakker

In rodents, kisspeptin-expressing neurons are localized in 2 hypothalamic brain nuclei (anteroventral periventricular nucleus/periventricular nucleus continuum [AVPv/PeN] and arcuate nucleus [ARC]) and modulated by sex steroids. By using wild-type (WT) and aromatase knockout (ArKO) mice (which cannot convert testosterone into estradiol) and immunohistochemistry, we observed that WT females show...

Journal: :Journal of molecular biology 2010
Patricia A Zunszain Stephen R Knox Trevor R Sweeney Jingjie Yang Núria Roqué-Rosell Graham J Belsham Robin J Leatherbarrow Stephen Curry

Picornavirus replication is critically dependent on the correct processing of a polyprotein precursor by 3C protease(s) (3C(pro)) at multiple specific sites with related but non-identical sequences. To investigate the structural basis of its cleavage specificity, we performed the first crystallographic structural analysis of non-covalent complexes of a picornavirus 3C(pro) with peptide substrat...

Journal: :Molecular pharmacology 2009
Ruoli Bai Michael C Edler Peter L Bonate Terry D Copeland George R Pettit Richard F Ludueña Ernest Hamel

Tasidotin, an oncolytic drug in phase II clinical trials, is a peptide analog of the antimitotic depsipeptide dolastatin 15. In tasidotin, the carboxyl-terminal ester group of dolastatin 15 has been replaced by a carboxy-terminal tert-butyl amide. As expected from studies with cemadotin, [(3)H]tasidotin, with the radiolabel in the second proline residue, was hydrolyzed intracellularly, with for...

Journal: :Molecular immunology 2000
D B De Oliveira E Harfouch-Hammoud H Otto N A Papandreou L J Stern H Cohen B O Boehm J Bach S Caillat-Zucman T Walk G Jung E Eliopoulos G K Papadopoulos P M van Endert

Specific and major histocompatibility complex (MHC)-restricted T-cell recognition of antigenic peptides is based on interactions of the T-cell receptor (TCR) with the MHC alpha helices and solvent exposed peptide residues termed TCR contacts. In the case of MHC class II-presented peptides, the latter are located in the positions p2/3, p5 and p7/8 between MHC anchor residues. For numerous epitop...

2015
Jonathan S. Wall Emily B. Martin Tina Richey Alan C. Stuckey Sallie Macy Craig Wooliver Angela Williams James S. Foster Penney McWilliams-Koeppen Ed Uberbacher Xiaolin Cheng Stephen J. Kennel

Amyloid is a complex pathologic matrix comprised principally of paracrystalline protein fibrils and heparan sulfate proteoglycans. Systemic amyloid diseases are rare, thus, routine diagnosis is often challenging. The glycosaminoglycans ubiquitously present in amyloid deposits are biochemically and electrochemically distinct from those found in the healthy tissues due to the high degree of sulfa...

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