The analysis of organotin compounds is becoming increasingly important in both environmental analysis and in food and consumer product analysis. This application note describes a retention time locked (RTL) gas chromatography/mass spectrometry (GC/MS) method for the analysis of derivatized organotin compounds. Three retention time locked libraries are made available, corresponding to three diff...

A series of diand tributyltin(IV) carboxylate compounds prepared by reacting the dibutyltin(IV) dichloride and tributyltin(IV) chloride respectively via the organotin(IV) oxide with the respective carboxylic acids have been tested for antifungal activity against Fusarium oxysporum and Aspergillus niger in potatoes dextrose agar. The compounds synthesized were mainly characterized with IR and UV...

Four new organotin(IV) complexes of the type [MeSnCl(dact)] (2), [BuSnCl(dact)] (3), [PhSnCl(dact)] (4) and [Ph2Sn(dact)] (5) were synthesized by the direct reaction of 2-hydroxyacetophenone-N(4)cyclohexylthiosemicarbazone [H2dact, (1)] and organotin(IV) chloride(s) in absolute methanol. The ligand [H2dact, (1)] and its organotin(IV) complexes (2–5) have been characterized by CHN analyses, mola...

Organotin polyethers are easily synthesized employing interfacial polymerization systems involving the reaction of hydroxyl-containing Lewis bases and organotin halides. A wide variety of organotin-containing polymeric products have been synthesized including those derived from natural and synthetic polymers such as lignin, xylan, cellulose, dextran, and poly(vinyl alcohol). Others have been sy...

An inductively coupled plasma mass spectrometer (ICP-MS) was used as a detector for gas chromatography (GC) and high performance liquid chromatography (HPLC) analysis of organotin compounds. ICP-MS is a highly sensitive detector with detection limits in the pg ng range, as well as enabling calibration by isotope dilution mass spectrometry (IDMS). Calibrating using isotopically labeled organotin...

Thermodynamic data such as the binding constants are vital parameters describing interactions between exotic trace compounds and biomolecules in biochemical property modeling. In this study, the stability constants of organometallic compound and protein complexes were studied by using capillary electrophoresis coupled with inductively coupled plasma mass spectrometry (CE-ICP-MS), considering it...

Five new organotin(IV) complexes of 2-hydroxyacetophenone-2-methylphenylthiosemicarbazone [H(2)dampt, (1)] with formula [RSnCl(n-1)(dampt)] (where R = Me, n = 2 (2); R = Bu, n = 2 (3); R = Ph, n = 2 (4); R = Me(2), n = 1 (5); R = Ph(2), n = 1 (6)) have been synthesized by direct reaction of H(2)dampt (1) with organotin(IV) chloride(s) in absolute methanol. The ligand (1) and its organotin(IV) c...

[5] Rice, C. D., Espourteille, F. A., and Huggett, R. J., Appl. Organometallic Chem. 6, in press. [6] Espourteille, F. A., Tributyltin in Oysters, Crassostrea virginica, and Sediments from the Chesapeake Bay, Masters Thesis, School of Marine Science, College of William and Mary, Gloucester Pt., VA (in preparation). [7] Huggett, R. J., Unger, M. A., and Westbrook, D. J., Organotin Concentrations...

Organotin compounds (OTCs) are characterized as having at minimum one covalent bond between carbon and tin atoms, usually denoted by the formula RnSnX4-n (n =1-3, R =aryl or alkyl, X =halogen ion a carboxylate, etc.). There several methods to synthesis organotin compounds, they Grignard Kocheshkov reactions, Wurtz reaction alkylation method. The has two stable state,(II) (IV). Sn(II) forms pyra...

An overview of the development of anti-tumor organotin derivatives in selected classes of compounds is presented and discussed. High to very high in vitro activity has been found, sometimes equaling that of doxorubicin. Solubility in water is an important issue, dominating the in vivo testing of compounds with promising in vitro properties. The cytotoxicity of the compounds was increased by the...