Metformin is an oral hypoglycemic agent of the biguanide class, and glimepiride sulfonylurea class frequently used to treat Type-II diabetes mellitus. Under certain conditions, overdose or long-term use metformin can cause lactic acidosis hypoglycemia. severe hypoglycemia in absence other anti-diabetic drugs. Potential mechanisms metformin-induced include decreased hepatic glucose production, a...

Background: Lichen planus is a pre-cancerous condition which immune mediated. It often linked with other autoimmune diseases such as Diabetes Mellitus. both Type 1 and 2 DM. Methods: A retrospective cross-sectional study that was conducted at Jinnah Sindh Medical University on data of patients coming to Oral Medicine OPD from January 2020- December 2022. Diabetic patient`s extracted, secondary ...

Diabetes mellitus is one of the most common endocrine diseases. Due to its complications, it caused significant mortality. Insulin and oral antidiabetic drugs were associated with many side effects. The search for more effective safer hypoglycemic agents important areas investigation. pharmacological investigations revealed that several medicinal plants showed effects by mechanisms. current rev...

OBJECTIVE To systematically review the evidence for the prevention of type 2 diabetes by pharmacological therapies. RESEARCH DESIGN AND METHODS Randomized controlled trials and cohort studies examining the effect of oral hypoglycemic agents, antiobesity agents, antihypertensive agents, statins, fibrates, and estrogen on the incidence of type 2 diabetes were identified from MEDLINE, EMBASE, th...

Background: Glybenclamide and metformin are two of the most common oral hypoglycemic drugs which are often used in treatment of type II diabetes mellitus. Toxicity due to these drugs may occur intentionally, accidentally, or even at the normal dosage because of the progression of such internal diseases as renal dysfunction. Methods: In this case series study, 59 patients poisoned with oral ...

Type 2 diabetes is a syndrome characterized by relative insulin deficiency, insulin resistance and increased hepatic glucose output. Medications used to treat the disease are designed to correct one or more of these metabolic abnormalities. Current recommendations of the American Diabetes Association (ADA) and European Association for the Study of Diabetes (EASD) include diet and exercise as fi...

Aloe buettneri was evaluated to confirm its hypoglycemic activity. The presence of quinone which seem to leave the hypoglycemic activity. Lyophilisate of A. buettneri leaf (LA) causes hypoglycemia only 2 h after its administration and is linked to the presence of quinone. Glycemia reduction with LA was significantly higher than that of Glibenclamide, the control. Glibenclamide and LA negatively...

BACKGROUND Several studies have indicated that type 2 diabetes mellitus is more common among schizophrenic patients than in the general population. In this study, we investigated whether the use of antipsychotic drugs in patients with diabetes leads to worsening of glycemic control. METHOD In this cohort study, patients with newly diagnosed type 2 diabetes were selected from the PHARMO Record...