The Center for Disease Control guidelines recommend desensitization to metronidazole in patients with trichomoniasis and hypersensitivity to metronidazole. There is only one published oral metronidazole desensitization protocol. The purpose of this study was to design a new, more gradual oral desensitization protocol to decrease systemic reactions that may occur when using the previously publis...

at present the only available management for food allergy is avoidance; however, abstaining from allergic foods can affect the quality of life. oral immunotherapy (oit) is an efficient method for increasing tolerance towards food allergens. the aim of this study was desensitizing patients above five years of age with wheat allergy and evaluating the safety and efficacy of oit for children with ...

1. Kim JS, Sinacore JM, Pongracic JA. Parental use of Epipen for children with food allergies. J Allergy Clin Immunol. 2005;116: 164–168. 2. Sicherer SH, Forman JA, Noone SA. Use assessment of selfadministered epinephrine among food-allergic children and pediatricians. Pediatrics. 2000;105:359–362. 3. Meglio P, Bartone E, Plantamura M, Arabito E, Giampietro PG. A protocol for oral desensitizati...

BACKGROUND Peanut allergy is a major public health problem that affects 1% of the population and has no effective therapy. OBJECTIVE To examine the safety and efficacy of oral desensitization in peanut-allergic children in combination with a brief course of anti-IgE mAb (omalizumab [Xolair]). METHODS We performed oral peanut desensitization in peanut-allergic children at high risk for devel...

REVIEWER COMMENTS. Egg is a common ingredient in a wide variety of foods. Desensitizing egg-allergic patients would reduce the risk of anaphylaxis associated with accidental ingestion and allow patients to consume a broader diet. Although the current study shows great promise, oral desensitization has significant inherent risks. Additional studies addressing patient selection, dosing, and long-...

BACKGROUND Aspirin exacerbated respiratory disease (AERD) consists of nasal polyposis, rhinosinusitis, asthma, and aspirin (ASA) sensitivity. OBJECTIVE This article details how to diagnose and treat AERD and describes the procedures associated with ASA challenge and desensitization, benefits associated with ASA desensitization, and appropriate doses for treatment. METHODS Criteria for diag...

Peanut and tree-nut allergies have increased dramatically in prevalence, especially children. Historically, children with food been treated through strict avoidance of the allergen. Recently, an oral preparation peanut allergen (Palforzia) was approved for immunotherapy (ie, desensitization) 4 to 17 years old. This article reviews its role allergies.

REVIEWER COMMENTS. Egg is a common ingredient in a wide variety of foods. Desensitizing egg-allergic patients would reduce the risk of anaphylaxis associated with accidental ingestion and allow patients to consume a broader diet. Although the current study shows great promise, oral desensitization has significant inherent risks. Additional studies addressing patient selection, dosing, and long-...

BACKGROUND Limited published evidence shows oral desensitization to be a potential intervention option for cow's milk protein (CMPs) allergy. OBJECTIVE The aim of this study was to evaluate the safety and efficacy of oral desensitization in 2-year-old children with cow's milk allergy, as a treatment alternative to elimination diet. METHODS A total of 60 children aged 24-36 months with IgE-m...