The importance of the genetic component in high myopia has been well established in population and family studies, but only a few candidate genes have been explored to date. The extracellular matrix small leucine-rich repeat proteins/proteoglycans (SLRPs) regulate collagen fibril diameter and spacing. Given their role in extracellular matrix assembly and expression in the eye, they are likely t...

The natural vitreous is a transparent, gelatinoid structure occupying four-fifths of the volume of the eye. It has a thin, membrane-like structure corresponding to the vitreous cortex that extends from the ora serrata to the posterior pole.1 It is somewhat spherical but slightly flattened meridionally, and it has a cup-shaped depression in its anterior side. It consists of about 99% water by we...