AIM Since interactome analysis of diseases can provide candidate biomarker panel related to the diseases, in this research, protein-protein interaction (PPI) network analysis is used to introduce the involved crucial proteins in Gastric adenocarcinoma (GA). BACKGROUND Gastric adenocarcinoma (GA) is the most common type of stomach cancer. There is no efficient diagnostic molecular method for G...

Antisera to a number of synthetic peptides predicted from nucleic acid sequences of oncogenes have been used to screen 483 urine samples of cancer patients, pregnant women, and normal controls for the presence of immunologically related proteins. Increased levels of oncogene-related proteins are found during neoplasia and pregnancy. The differential detection of these oncogene-related proteins ...

Cancers overexpressing the ERBB2 oncogene are aggressive and associated with a poor prognosis. Trastuzumab is an specific recombinant antibody employed for treatment of these diseases since it blocks signaling causing growth arrest survival inhibition. While effects on cancer cells well known, those extracellular vesicles (EVs) released from scarce. This study focused ERBB2+ breast aimed to est...

Abstract By 2003, the Human Genome project had been completed; however, it turned out that 97% of genome sequences did not encode proteins. The explanation came later when was found untranslated DNA contain for short microRNAs (miRNAs) and long noncoding RNAs produce any mRNAs or tRNAs, but instead were involved in regulation gene expression. Initially identified cytoplasm, miRNAs have all cell...

Purpose: To investigate the effect of resveratrol (RSV) on bortezomib (BTZ)-resistant multiple myeloma (MM) cells, and to elucidate underlying mechanism action.
 Methods: H929 cell lines were exposed BTZ for 8 months establish BTZ-resistant MM model. Cell proliferation was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Apoptosis measured using annex...

Cervical cancer is a disease characterized by the growth of abnormal cells in cervical tissue. mostly caused Human Papillomavirus (HPV) types 16 and 18. The role genetic factors development malignancy mediated presence mutation HPV oncogene, especially oncogenes E6 E7. Oncogenic proteins E7 initiate dysregulation cellular proliferation apoptotic mechanisms targeting tumor suppressor proteins, s...