Neglected tropical diseases (NTD), a broad set of infectious prevalent in and subtropical environments, are widely known to affect individuals with limited resources underserved communities. Nigeria is one the countries highest cases NTD, an estimated 100 million people country at risk for least NTD. In Nigeria, NTD master plan recognizes behavioural change communication as important part its s...

An N-terminal-domain (NTD) and adjacent catalytic body (CB) make up subunit-α of ribonucleotide reductase (RNR), the rate-limiting enzyme for de novo dNTP biosynthesis. A strong linkage exists between ligand binding at the NTD and oligomerization-coupled RNR inhibition, inducible by both dATP and nucleotide chemotherapeutics. These observations have distinguished the NTD as an oligomeric regula...

Periconceptional folic acid (FA) reduces neural tube defect (NTD) risk, but seems to have a varying effect per NTD subtype. We aimed to study the effect of FA supplementation on NTD subtype distribution using data from EUROCAT Northern Netherlands. We included all birth types with non-syndromal NTDs born in 1997-2012. By Fisher's exact test we analyzed possible differences in NTD subtype distri...

RNA helicase A (RHA) undergoes nuclear translocation via a classical import mechanism utilizing karyopherin beta. The nuclear transport domain (NTD) of RHA is known to be necessary and sufficient for its bi-directional nuclear trafficking. We report here that arginine methylation is a novel requirement for NTD-mediated nuclear import. Nuclear translocation of glutathione S-transferase (GST)-NTD...

Replication protein A (RPA) is a heterotrimeric, multi-functional protein that binds single-stranded DNA (ssDNA) and is essential for eukaryotic DNA metabolism. Using heteronuclear NMR methods we have investigated the domain interactions and ssDNA binding of a fragment from the 70 kDa subunit of human RPA (hRPA70). This fragment contains an N-terminal domain (NTD), which is important for hRPA70...

Human exposures to volatile organic compounds (VOCs) are associated with a wide range of health problems. Due to these adverse effects of VOCs on the human health, determination of trace levels of VOCs is very important for accurate assessment of indoor and outdoor exposure. Solid phase microextraction (SPME), needle trap device (NTD) and hollow fiber- liquid phase microextraction (HF-LPME) are...

OBJECTIVE To examine the association between the risk of neural tube defects (NTD) and maternal serum vitamin B12, folate and homocysteine in a high-risk area of China. DESIGN A case-control study was carried out in Luliang mountain area of Shanxi Province. SUBJECTS/SETTING A total of eighty-four NTD pregnancies and 110 matched controls were included in the study; their serum vitamin B12 an...

Nicotinic acetylcholine receptors (nAChRs) play a fundamental role in nervous signal transmission, therefore various antagonists and agonists are highly desired to explore the structure and function of nAChRs. Recently, a novel dimeric αD-conotoxin GeXXA was identified to inhibit nAChRs by binding at the top surface of the receptors, and the monomeric C-terminal domain (CTD) of αD-GeXXA retains...