statistical data from 1966 till 1995 showed that neural tube defects, in the american continent, venezuela had the highest prevalence of 38.9 and some latin american countries showed the low of 7.7. in europe, norway had the highest prevalence of 68, and denmark the lowest, 5.8. in asia, india had the highest of 181.8 and japan the lowest of 10. in africa, nigeria had the highest of 70 and negr...

BACKGROUND Neural tube defect (NTD) prevalence in northern China is among the highest worldwide. Dealing with the NTD situation is ranked as the number one task in China's scientific development plan in population and health field for the next decade. Physical and social environments account for much of the disease's occurrence. The environmental determinants and their effects on NTD vary acros...

We identified a nitidine- (NTD-) accumulating organelle and evaluated the net cytotoxicity of accumulated NTD. To evaluate tumor cell selectivity of the drug, we evaluated its selective cytotoxicity against 39 human cancer cell lines (JFCR39 panel), and the profile was compared with those of known anticancer drugs. Organelle specificity of NTD was visualized using organelle-targeted fluorescent...

In this work, we develop first near-complete 3D models for NTD-hXPB the N-terminal protein domain of the human transcription factor XPB. The results are very significant as NTD-hXPB plays a critical role in the synthesis of proteins (specifically transcription) and DNA damage repair (specifically nucleotide excision repair). NTD-hXPB is directly implicated in rare diseases XP-B, XP-CS, and TTD2...

Introduction Parasitic helminth infections, including lymphatic filariasis (LF), schistosomiasis and soiltransmitted helminthiasis (STH), are prevalent and often co-exist among poor populations in the developing world. Schistosomiasis and STH have particularly high prevalence among school-aged children, and LF is also more prevalent in this population than previously thought. Ivermectin (IVM) a...

The burden of schistosomiasis (SCH) in children and infants Until recently, a paucity of information fueled the debate of whether national neglected tropical disease control programs should treat young children with praziquantel (PZQ). International dialogue was driven by uncertainty regarding the distribution and prevalence of SCH in children under 5, and whether targeting them with preventati...