Introduction: Oral squamous cell carcinoma (OSCC) is the world's sixth malignant disease with multifactorial causes. Nitrosamine compounds can be found in saliva and used as a biomarker for early detection of oral cancer. Carcinogenic nitrosamines derived from tobacco use contact normal cavity cells. It affects process controlling growth by interfering DNA translation. This study aims to determ...

2. Furthermore, NIPH was asked by Klif to evaluate existing risk estimates for Nnitrosodimethylamine (NDMA). This includes an evaluation of EPA/IRIS risk estimates for drinking water and air, and other risk estimates of this nitrosamine in Europe or Canada. Klif wanted an evaluation of the validity of the values, how they can be used, and how they should be interpreted. NIPH was also asked to c...

Knowledge of N-nitrosamine precursors from dissolved organic matter (DOM) is important for water professionals to better control N-nitrosamine formation. The characterization of DOM from the Luan River in Northern China was conducted using Amberlite XAD resins and ultra-filtration methods. N-nitrosamine formation potentials were investigated for various DOM fractions. The removal of the DOM dur...

Combined hepatocellular and cholangiocarcinoma with sarcomatous transformation was first recognized in Ramathibodi Hospital in 2005. This variant of carcinoma has been increasingly reported particularly from Asian countries. Dedifferentiation of the epithelial component to various sarcomatous components is likely the underlying mechanism. The causative factors of hepatocarcinogenesis in Thailan...