A series of nitrofuran-based compounds were identified as inhibitors of estrogen signaling in a cell-based, high-throughput screen of a diverse library of small molecules. These highly related compounds were subsequently found to inhibit topoisomerase II in vitro at concentrations similar to that required for the inhibition of estrogen signaling in cells. The most potent nitrofuran discovered i...

A nitrofuran-containing medium, FTO agar, supported the growth of Micrococcus and prevented the growth of Staphylococcus. Its potential as a differential medium is considered worthy of clinical trial.

Several antimicrobials act by inhibiting the synthesis of nucleic acids (rifamycins, sulfamides, diaminopyridines), modifying their conformation (quinolones, coumarins) or causing irreversible lesions (nitroimidazoles, nitrofurans). The resistance mechanisms are: a reduction in intracytoplasmic accumulation, modification of the target or the production of a new low-affinity target and, more rar...

5-Nitrofurans have been used in the study of chemical carcinogenesis. There is substantial evidence that N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide (FANFT) is deformylated to 2-amino-4-(5-nitro-2-furyl)thiazole (ANFT) in the process of FANFT-induced bladder cancer. Paradoxically, ANFT is less potent as a uroepithelial carcinogen than FANFT when fed to rats. Feeding aspirin with FANFT to rats...

The general antibacterial action in vitro of a variety of furan derivatives substituted in the 5 position with a nitro group has been reported by Dodd and Stilhnan (1, 2). That the presence of the nitro group is essential was established by comparison of the activities with those of the corresponding non-nitrated derivatives. All the nitrofurans except those limited by insolubility exhibited a ...

The general antibacterial action in vitro of a variety of furan derivatives substituted in the 5 position with a nitro group has been reported by Dodd and Stilhnan (1, 2). That the presence of the nitro group is essential was established by comparison of the activities with those of the corresponding non-nitrated derivatives. All the nitrofurans except those limited by insolubility exhibited a ...

Dodd and Stillman (1944) described the antibacterial activity of the nitrofurans, and nltrofurantoin was synthesized by the Eaton Laboratories in 1952. Since that time this substance has been given extensive clinical trials in the United States of America in infections of the urinary tract. Limited clinical trials were recently reported in this country (Heffernan, Kippax, and Pamplin, 1955), an...