Background: Many psychiatric patients have nicotine and other substance dependence. Objective: To determine the prevalence of nicotine and opium dependence among psychiatric in-patients inKerman, a city in southwesternIran. Methods: Three groups of psychiatric inpatients, chronic medical patients and a sample from local population, each including 400 subjects were selected.  Nicotine dependence...

Background: Nicotine as a toxic agent in cigarette has detrimental effects on reproduction. The aim of this study was to evaluate effects of of nicotine on germ and somatic cells in adult mouse testis. Materials and Methods: Male mice were divided into four groups. Group A or controls, groups of B, C and D were treated with nicotine intraperitoneally in doses of 0.1, 0.2 and 0.4 mg/100 g body w...

previous studies in humans and animals have reported that nicotine administration decreases body weightand caloric intake. opiate and cigarette have been used concomitantly as drug abuse. the aim of the present study was, therefore, to analyze the effect of chronic co-administration of nicotine and morphine on food intake, body weight and on some feeding-associated peptides. all experiments wer...

background: nicotiana tobacco contains large amounts of alkaloid nicotine. tobacco plant is used for smoking and causes many health problems since it is high in nicotine which is one of the widely-recognized toxic compounds with serious side effects for different body organs. reducing nicotine content of this plant is a way to reduce its health hazards in cigarette smokers. utilizing the new me...

Nicotine transdermal systems are being used as an aid to smoking cessation programs. As the kinetics of nicotine delivery is important in success of a smoking cessation program, rapid and high input of nicotine is required, which is not possible by passive methods and requires enhancement strategies such as iontophoresis. Iontophoretic permeation, of nicotine looks promising, based on published...

Administration of nicotine leads to incentive and behavioral tolerance in human and animals. Ascorbic acid administration inhibits some effects of nicotine. In the present study, the effects of ascorbic acid administration on the expression and development of nicotine-induced behavioral tolerance in female Swiss-Webster mice (20-25 g) was investigated. Animals were injected with nicotine (0.5 m...

Administration of nicotine leads to incentive and behavioral tolerance in human and animals. Ascorbic acid administration inhibits some effects of nicotine. In the present study, the effects of ascorbic acid administration on the expression and development of nicotine-induced behavioral tolerance in female Swiss-Webster mice (20-25 g) was investigated. Animals were injected with nicotine (0.5 m...

Repeated administration of nicotine causes incentive and behavioral sensitization in animals. Ascorbic acid administration inhibits some effects of nicotine. In the present study, the effect of ascorbic acid administration on nicotine-induced behavioral sensitization in Male Swiss-Webster mice (20-25 g) was investigated. Animals were injected with nicotine (0.25 mg/kg, i.p.) once daily for seve...

abstract  introduction: smoking is an important risk factor of coronary artery disease. nicotine replacement therapy (nrt) for smoking cessation should be considered, especially in coronary patients. methods: twenty-four healthy smokers, smoking an average of 20 cigarettes a day for 15 years and with moderate cigarette dependence (according to the fagershtrum questionnaire score) were randomly ...

Nicotine is widely used in pharmaceutical industries, especially for smoking cessation the form of transdermal patches. gel patches has limitations from nicotine instability and high volatility. Thus, a preservation technique needed. In this study, encapsulation process using methyl-?-cyclodextrin (M?CD) investigated compared with ?-cyclodextrin (?CD) to evaluate skin permeation nicotine. The M...