Neonatal lupus erythematosus is an immune-mediated disease that rarely is associated with congenital heart block. Transient hepatitis, thrombocytopenia and anemia can also occur. We describe a case of neonatal lupus erythematosus and review the clinical and laboratory manifestations of this rare disease. Its only clinical sign might be an annular facial rash. The rash is usually diagnostic, but...

Neonatal Lupus Erythematosus (NLE) is an uncommon condition manifesting with congenital complete heart block and occasionally other manifestations like hepatitis. Neonatal Lupus with severe cholestasis with positive anti SS-A/Ro and anti SS-B/La antinuclear antibodies in the mother and child is being reported.

Neonatal lupus erythematosus is an uncommon passive autoimmune disease in which there is transplacental passage of anti-Ro/SSA and/or anti-La/SSB or anti-U1RNP maternal autoantibodies. Its common clinical manifestations include cardiac disease, notably congenital heart block, cutaneous lupus lesions, and hematologic problems. During the past decade, it has become clear that hepatobiliary diseas...

Background: Systemic lupus erythematosus is a systemic autoimmune disorder with unclear etiology. The importance of some genes in the development of systemic lupus erythematosus has been implicated. The gene polymorphism in codon 72 has attracted a lot of attention and its role in the occurrence or progression of many cancers and autoimmune diseases especially systemic lupus erythematosus has ...

Neonatal lupus erythematosus (NLE) refers to a clinical spectrum of cutaneous, cardiac, and systemic abnormalities observed in newborn infants whose mothers have autoantibodies against Ro/SSA and La/SSB. The condition is rare and usually benign and self-limited but sometimes may be associated with serious sequelae. We review the pathophysiology, clinical features, and management of infants with...

Neonatal lupus erythematosus (NLE) or neonatal lupus syndrome (NLS) is a rare syndrome seen in 1-2% of neonates with auto-antibodies to SSA/Ro, SSB/La and or U1 RNP, passively transferred transplacentally from the mother who is either asymptomatic or having manifestations of Sjogren’s syndrome, SLE or other systemic rheumatic disease, characterized by cutaneous, cardiac or rarely both clinical ...

We describe case report of a 45 days old male baby with neonatal lupus erythematosus, who presented with 3rd degree congenital heart block and depigmented skin lesions on face and upper part of body. Diagnosis of the baby was confirmed by anti nuclear levels and skin biopsy.

conclusions mothers with sle should be screened and closely followed up during pregnancy for the development of fetal atrioventricular (av) block. case presentation a term infant with fetal bradycardia, detected at the 23rd gestational age, was diagnosed with chb due to nls and was successfully treated with a permanent epicardial pacemaker. the patient was reported here due to rarity of the pro...

thymoma is a term that should be restricted to neoplasms of thymic epithelial cells, irrespective of the presence or the number of lymphocytes. the usual location of thymoma is the antrosuperior mediastinum; however, this tumor can also occur in other mediastinal compartments, in the neck, within the thyroid gland, in the pericardial cavity, the pulmonary hilum, within the lung parenchyma, or t...