The conclusions stated after evaluation of 49 test results are presented in Table 1 for the in vivo mutagenicity and in Table 2 for in vitro mutagenicity. To evaluate the mutagenicity of the product, the criteria in point 4.2.2 of the Annex VI to the Directive 67/548/EEC are used. The tests using intra-peritoneal administration are not taken into account to determine the mutagenicity of hydroqu...

Phenyl glycidyl ether and 6 para-subst i tuted derivatives, the methoxy, tert-butyl, methyl, chloro, bromo and nitro compounds, were tested in the Ames' test for mutagenicity. With the exception of the tert-butyl derivative in TA1535, all 7 compounds were mutagenic in both strains TA100 and TA1535. Electron-donating groups in the para position decreased mutagenicity while electron-withdrawing g...

We investigated urinary mutagenicity and colorectal adenoma risk in a clinic-based, case-control study of currently nonsmoking cases (n 143) and controls (n 156). Urinary organics were extracted by C18/methanol from 12-h overnight urine samples, and mutagenicity was determined in Salmonella YG1024 S9 (Ames test). Adenoma risk was 2.4-fold higher in subjects in the highest versus the lowest quin...

A recent report (Calabrese et al., Mutat. Res. 726 (2011) 91-97) concluded that an analysis of Ames test mutagenicity data provides evidence of hormesis in mutagenicity dose-response relationships. An examination of the data used in this study and the conclusions regarding hormesis reveal a number of concerns regarding the analyses and possible misinterpretations of the Salmonella data. The cla...

The mutagenicity of 17 aliphatic epoxides was determined using the specially constructed mutants of Salmonella typhimurium developed by Ames. The activity of these epoxides together with those reported in the literature as mutagens in strains TA100 and TA1535 depended on the degree of substitution around the oxirane ring. Monosubstituted oxiranes were the most potent mutagens in both strains. 1...

Chlorination of humic and fulvic acid results in the formation of direct-acting mutagenicity, detectable in the Salmonella/microsome assay (Ames test). This mutagenicity is being characterized as part of an overall effort aimed at evaluating potential health risks associated with the presence of mutagenic chemicals in drinking water. A number of chlorinated organic compounds, including several ...

A review of the literature on the mutagenicity of textile dye products is presented in this article. This review discusses genetic hazards associated with the production and use of textile dyes throughout the world. Mutagenicity of azo and non azo dyes has been considered due to extensive recent data on the carcinogenicity and mutagenicity of this group of dyes. In addition, a section on Salmon...

results: the lowest concentrations of nzvi that inhibited the visible growth (mic) of e. amylovora, x. oryzae, b. cereus and streptomyces spp. were 625, 550, 1250 and 1280 ppm, respectively. the minimum bactericidal concentration (mbc) for e. amylovora and x. oryzae were 10,000 and 5,000 ppm of nzvi, respectively. mbc was not observed for the gram positive bacteria. no bacteriostatic and bacter...

A large and extensive body of data on the use of human liver S9 fractions in the Salmonella mutagenicity test (Ames test) is presented; the data were obtained from a collaborative study by JEMS/BMS (Bacterial Mutagenicity Test Study Group) members and the Human and Animal Bridging Research Organization (HAB). In this study, the mutagenicity of 58 chemicals, many of which were judged to be human...

Few reports have characterized mutagenic compounds in respirable airborne particles (<2.5 micrometers in diameter; PM2.5) collected at different sites on a regional scale (hundreds of km). Previously, we reported differences in the human (h1A1v2) cell mutagenicity of whole and fractionated organic extracts of PM2.5 samples collected in Boston, MA, Rochester, NY, and Quabbin Reservoir, a rural s...