Mullerian Inhibiting Substance (MIS), a 140-kDa homodimer glycoprotein member of the TGF-beta superfamily of biological-response modifiers, causes regression of the Mullerian ducts in developing male embryos. MIS also can induce growth arrest and apoptosis in ovarian and cervical cancer cell lines. The embryonic progenitor of the ovarian and cervical epithelium is the coelomic epithelium, the s...

Herlyn-Werner-Wunderlich syndrome also known as uterus didelphys with obstructing hemivaginal septum and ipsilateral renal agenesis is a rare syndrome with only a few hundred reported cases described since 1922. Uterus Didelphys is a type of lateral fusion disorder of mullerian ducts. Mullerian duct anomalies have an incidence of 2–3%, while obstructing hemivaginal septum and ipsilateral renal ...

Mutations were introduced into conserved steroidogenic factor 1 (SF1)- and SOX9-binding sites within the endogenous mouse Mullerian inhibiting substance (Mis) promoter. Male mice homozygous for the mutant SF1-binding site correctly initiated Mis transcription in fetal testes, although at significantly reduced levels. Surprisingly, sufficient MIS was produced to eliminate the MUllerian ducts. In...

The Anti-Mullerian hormone (AMH), which is produced by fetal Sertoli cells, is responsible for regression of Mullerian ducts, the anlagen for uterus and Fallopian tubes, during male sex differentiation. Ovarian granulosa cells also secrete AMH from late in fetal life. The patterns of expression of AMH and its type II receptor in the post-natal ovary indicate that AMH may play an important role ...

Abnormal fusion of the mullerian ducts causes variyng degrees of congenital uterine anomalies, associated with reproductive problems. Twin gestation in a case of bicornuate uterus is extremely rare and with a poor reproductive performance. We are reporting this case because there are only a few cases, less than 20, in previous reports.

Rudimentary horn is an anatomic variant of unicornuate uterus which a mullerian duct anomaly resulting from the incomplete fusion ducts. The prevalence congenital uterine malformations about 3.2%Pregnancy in rudimentary extremely rare condition occurring 1 76,000 to 1,40,000 pregnancies. Unicornuate with maybe associated gynecological and obstetric complications like infertility, endometriosis,...

Anti-Mullerian hormone (AMH) is a protein that inhibits the development of the mullerian ducts (paramesonephric ducts) in the male embryo. AMH prevents the development of the mullerian ducts into the uterus and other mullerian structures in the first 8 weeks of gestational age. AMH is produced by granulosa cells of the ovary during the reproductive years and controls the formation of primary fo...

Female infertility accounts for two-thirds of all infertility problems, and it can be due to tubal, ovarian, and/or uterine factors. Tuboperitoneal disease is thought to be a contributing factor to infertility for up to 40% of infertile couples. Imaging-led evaluations of infertility focus primarily on the uterine cavity and fallopian tubes. Transvaginal ultrasound plays a vital role. Hysterosa...

Received December 2009 Accepted February 2010 INTRODUCTION Prostatic cysts are rare entities, usually asymptomatic, and detected incidentally during transrectal or abdominal ultrasonography. Mostly, they originate from the posterior area of the prostate, such as the mullerian ducts and utricle, as an embryological remnant.(1) Symptomatic prostatic cysts usually present with recurrent urinary tr...

Mullerian cysts are rare cystic lesions that represent remnants of ducts. The clinical presentation usually involves swelling or symptoms large cyst-size compression adjacent structures. preoperative diagnosis is very challenging due to the lack specific features, and precise reached with histopathological examination. In this report, we discuss a case involving 26-year-old woman who visited ou...