• The literature contains many conflicting reports concerning the role of acid niucopolysaccharides and lipids in the pathogeneyis of coronary atherosclerosis. The most notable controversy concerns the earliest morphological alteration in atherogenesis. Some investigators hold that the accumulation of acid mucopolysaccharides is the reaction to a primary deposition of lipid, while others hold t...

LTHOUGH A VAST AMOUNT OF LITERATURE has been published in recent years on the subject of hyaluronic acid and hyaluronidase, owing to the importance of a biologic function which has been ascribed to these two substances, no satisfactory method yet exists for the determination of minute quantities of hyaluronic acid or other mucopolysaccharides. Various mucopolysaccharides form stable dispersions...

The influence of estradiol upon incorporation of isotopes into the sulfated acid mucopolysaccharides of connective tissues of the rat has been studied. Administration of the hormone for 3 weeks significantly reduces the in vitro incorporation of S(35)-sulfate into cartilage and thoracic aorta without significantly altering the amount of hydrolyzable sulfate in these tissues. The reduction of su...

The turnover of the acid mucopolysaccharides, hyaluronic acid (HA) and chondroitinsulfuric acid (CSA), of skin has been studied in normal rats (1) and in animals treated with the adrenocortical hormones, 17-hydroxycorticosterone and 11-dehydro-17-hydroxycorticosterone (2). It was shown that the administration of these adrenal steroids to otherwise normal rats resulted in a decreased turnover of...

The excretion of mucopolysaccharides normally found in urine (chondroitin, chondroitin sulfates A and C, keratosulfate, and heparitin sulfate) is increased approximately twofold in patients with progresive exophthalmos. A threefold elevation of total serum mucopolysaccharides is also found. These increases are unrelated to thyroid function.

PURPOSE. To examine changes in acid mucopolysaccharides and collagen expression during meniscal degeneration, tearing, and repair, using menisci excised from knee joint surgeries. METHODS. Menisci excised from 23 patients aged 15 to 80 years who underwent meniscal surgery for flap and bucket handle tears (n=11) and total knee arthroplasty (TKA) for osteoarthritis (n=12) were examined histologic...

Urinary excretion of acid mucopolysaccharides of varying composition and amount has been found in a number of rare diseases, mainly affecting the connective tissues. Recently excretion of chondroitin sulphate and hyaluronic acid in the urine of a patient with mastocytosis has been described by Asboe-Hansen and Clausen (1963). Evidence of the presence of acid mucopolysaccharides in different org...

and their growth medium demonstrate the ability of synovial sarcoma cells to synthesize and secrete various sulfated mucopolysaccharides. The sulfated species that is predominant inside the cell appears to be a heparin-related mucopolysaccharide. These findings clarify the histochemical observations that indicate the presence, in vivo, of mucopolysaccharide species resistant to degradation by h...

Acid mucopolysaccharides have been extracted from whole rabbit polymorphonuclear leucocytes and from the cytoplasmic granules of these cells. The leucocyte acid mucopolysaccharides can be separated into two fractions by the solubility of their CPC complexes in solutions of differing salt concentration. One of these fractions appears to be identical with hyaluronic acid; the other appears to be ...