background: we often see patients with a thin endometrium in art cycles, in spite of standard and adjuvant treatments. improving endometrial growth in patients with a thin endometrium is very difficult. without adequate endometrial thickness these patients, likely, would not have reached embryo transfer. objective: we planned this study to investigate the efficacy of intrauterine granulocyte co...

prevalence of abortion is higher in women with autoimmune thyroid disease. in the majority of cases, however, no abnormality of thyroid function is detected despite the high levels of antithyroid antibodies. the direct influence of such harmful autoantibodies in female reproductive organs may serve a role in pregnancy loss. in this study, expression of thyroglobulin in the reproductive tissues ...

The effect of trimegestone-based sequential hormone replacement therapy (HRT) on the distribution of endometrial leukocytes and Ki-67 expression was investigated and the findings compared with the endometrium of the natural cycle. Endometrial cells positive for CD45(+), CD56(+), CD3(+), Ki-67(+) and CD45(+)/Ki-67(+) antigens were immunohistochemically evaluated in samples from postmenopausal wo...

Calcium ions play an important role in the establishment and maintenance of pregnancy, but molecular and cellular regulatory mechanisms of calcium ion action in the uterine endometrium are not fully understood in pigs. Previously, we have shown that calcium regulatory molecules, transient receptor potential vanilloid type 5 (TRPV6) and calbindin-D9k (S100G), are expressed in the uterine endomet...

Background MIF via its receptor, CD74, initiates a signaling cascade that leads to proliferation and survival of cells. Also, MIF binding to CD74 activates p38 signaling pathways that lead to positive effect on the expression of COX-2. The aim of this study was to evaluate the gene expression profile of MIF, CD74 and COX-2 in normal, ectopic and eutopic endometrium during menstrual cycle. The e...

Ovarian stimulation for IVF is known to affect luteal phase function. The endometrium in IVF cycles is thus subject to an altered endocrinological environment and to a possible direct effect of the ovarian stimulation therapy. Factors influencing the endometrial receptivity in such cycles are poorly understood. Studies comparing the endometrium in IVF cycles with natural cycles as controls have...

Background Is G-CSF has any effects on cancelled ART cycle due to thin endometrium. This study showed the beneficial effects of G-CSF on thin endometrium. In two previous studies, some beneficial effects were reported and in another no effects were seen. MaterialsAndMethods In a nonrandomized clinical trial, fifteen cases were evaluated from June 2011 till September 2012. All cases had history ...